The invention is related to a process for preparing a iodinating X-rays contrast agent. More specifically, it relates to a process for the preparation of N,N'-bis-(2,3-dihydroxypro-pyl)-5-hydroxy-2,4,6-triiodo-1,3-benzenedicarboxaniide (I) by electrochemical iodination of N,N'-(2,3-dihydroxypro-pyl)-5-hydroxy-1,3-benzenedicarboxamide (II) with molecular iodine (I2) which is in situ electrochemically generated from a source of iodide ions (I−). The iodide ions(I−) are obtained by the dissolution of hydrogen iodide (HI) or an alkali metal iodide in the reaction medium or produced during thereactionofN,N'-(2,3-dihydroxypropyl)-5-hy- droxy-1,3-benzenedicarboxamide withI2.The invention also relates to the use of the intermediate compound of formula (I),obtainedthroughtheaboveelectrochemical iodination ofcompound(II),inthepreparationofN,N'-bis[2,3-dihydroxypropyl]-5(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide (iomeprol).

ELECTROCHEMICAL IODINATION OF N,N'-(2,3-DIHYDROXYPROPYL)-5-HYDROXY-1,3-BENZENEDICARBOXAMIDE / L. Lattuada, C. Cavallotti, G. Battista Giovenzana, F. Uggeri, A. Minguzzi, A. Vertova, L. Sorti, C. Morelli.

ELECTROCHEMICAL IODINATION OF N,N'-(2,3-DIHYDROXYPROPYL)-5-HYDROXY-1,3-BENZENEDICARBOXAMIDE

A. Minguzzi;A. Vertova;L. Sorti;C. Morelli
2024

Abstract

The invention is related to a process for preparing a iodinating X-rays contrast agent. More specifically, it relates to a process for the preparation of N,N'-bis-(2,3-dihydroxypro-pyl)-5-hydroxy-2,4,6-triiodo-1,3-benzenedicarboxaniide (I) by electrochemical iodination of N,N'-(2,3-dihydroxypro-pyl)-5-hydroxy-1,3-benzenedicarboxamide (II) with molecular iodine (I2) which is in situ electrochemically generated from a source of iodide ions (I−). The iodide ions(I−) are obtained by the dissolution of hydrogen iodide (HI) or an alkali metal iodide in the reaction medium or produced during thereactionofN,N'-(2,3-dihydroxypropyl)-5-hy- droxy-1,3-benzenedicarboxamide withI2.The invention also relates to the use of the intermediate compound of formula (I),obtainedthroughtheaboveelectrochemical iodination ofcompound(II),inthepreparationofN,N'-bis[2,3-dihydroxypropyl]-5(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide (iomeprol).
Bracco Imaging SpA
US 2024/0271295 A1
US18/694,306
EP2022076320
15-ago-2024
Settore CHEM-02/A - Chimica fisica
https://worldwide.espacenet.com/patent/search?q=pn=US2024271295A1
ELECTROCHEMICAL IODINATION OF N,N'-(2,3-DIHYDROXYPROPYL)-5-HYDROXY-1,3-BENZENEDICARBOXAMIDE / L. Lattuada, C. Cavallotti, G. Battista Giovenzana, F. Uggeri, A. Minguzzi, A. Vertova, L. Sorti, C. Morelli.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1119202
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