In mammals, most of the genome is transcribed to generate a large and heterogeneous variety of non-protein coding RNAs, that are broadly grouped according to their size. Long noncoding RNAs include a very large and versatile group of molecules. Despite only a minority of them has been functionally characterized, there is emerging evidence indicating long noncoding RNAs as important regulators of expression at multiple levels. Several of them have been shown to be modulated during myogenic differentiation, playing important roles in the regulation of skeletal muscle development, differentiation and homeostasis, and contributing to neuromuscular diseases. In this chapter, we have summarized the current knowledge about long noncoding RNAs in skeletal muscle and discussed specific examples of long noncoding RNAs (lncRNAs and circRNAs) regulating muscle stem cell biology. We have also discussed selected long noncoding RNAs involved in the most common neuromuscular diseases.

Long non-coding RNAs and their role in muscle regeneration / B. Biferali, E. Mocciaro, V. Runfola, D. Gabellini (CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY). - In: Muscle Stem Cells / [a cura di] Michael A. Rudnicki, F. Jeffrey Dilworth. - [s.l] : Elsevier, 2024. - ISBN 978-0-128-23435-8. - pp. 433-465 [10.1016/bs.ctdb.2024.02.010]

Long non-coding RNAs and their role in muscle regeneration

E. Mocciaro
Co-primo
;
2024

Abstract

In mammals, most of the genome is transcribed to generate a large and heterogeneous variety of non-protein coding RNAs, that are broadly grouped according to their size. Long noncoding RNAs include a very large and versatile group of molecules. Despite only a minority of them has been functionally characterized, there is emerging evidence indicating long noncoding RNAs as important regulators of expression at multiple levels. Several of them have been shown to be modulated during myogenic differentiation, playing important roles in the regulation of skeletal muscle development, differentiation and homeostasis, and contributing to neuromuscular diseases. In this chapter, we have summarized the current knowledge about long noncoding RNAs in skeletal muscle and discussed specific examples of long noncoding RNAs (lncRNAs and circRNAs) regulating muscle stem cell biology. We have also discussed selected long noncoding RNAs involved in the most common neuromuscular diseases.
Chromatin; CircRNA; DMD; FSHD, muscular dystrophy; LncRNA; Muscle stem cells (MuSCs); NcRNA; Satellite cells (SCs); Transcription; Translation
Settore BIOS-08/A - Biologia molecolare
Settore BIOS-14/A - Genetica
Settore BIOS-11/A - Farmacologia
Settore BIOS-12/A - Anatomia umana
Settore BIOS-13/A - Istologia ed embriologia umana
2024
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1116138
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