Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study

Semenchuk, J.; Naito, Y.; Charman, S.C.; Carr, S.B.; Cheng, S.Y.; Marshall, B.C.; Faro, A.; Elbert, A.; Gutierrez, H.H.; Goss, C.H.; Karadag, B.; Burgel, P.; Colombo, C.; Salvatore, M.; Padoan, R.; Daneau, G.; Harutyunyan, S.; Kashirskaya, N.; Kirwan, L.; Middleton, P.G.; Ruseckaite, R.; de Monestrol, I.; Naehrlich, L.; Mondejar-Lopez, P.; Jung, A.; van Rens, J.; Bakkeheim, E.; Orenti, A.; Zomer-van Ommen, D.; da Silva-Filho, L.V.R.; Fernandes, F.F.; Zampoli, M.; Stephenson, A.L.; Kasmi, I.; Drali, O.; Burghart, S.; Lakatos-Krepcik, A.; Eder, J.; Jaksch, P.; Kainz, K.; Kallinger, M.; Leitner, A.; Mozdzen, M.; Pfleger, A.; Renner, S.; Stadlinger, M.; Thir, C.; Nuriyev, E.; Boboli, H.; De Wachter, E.; Dupont, L.; Gohy, S.; Hanssens, L.; Knoop, C.; Lammertyn, E.; Nowé, V.; Pirson, J.; Thimmesch, M.; Van Braeckel, E.; Van Hoorenbeeck, K.; Vanderhelst, E.; Filho, E.P.; Athanazio, R.A.; Martins, V.D.C.; Duarte, M.C.; Monte, L.D.F.V.; de Fuccio, M.B.; Knabben, A.D.S.C.; Melloti, R.; Meneses, D.G.; Petrova, G.; Tješić-Drinković, D.; Dugac, A.V.; Bambir, I.; Yiallouros, P.; Bilkova, A.; Drevinek, P.; Macek, M.; Olesen, H.V.; Pressler, T.; Fouda, E.M.; Nasr, S.; Weldetsadik, A.Y.; Al-iede, M.; Abdrakhmanov, O.; Corvol, H.; Lemonnier-Videau, L.; Abely, M.; Piccini, C.B.; Belleguic, C.; Bihouee, T.; Billon, Y.; Bui, S.; Camara, B.; Cheraud, M.; Chiron, R.; Duet, E.C.; Cosson, L.; Dalphin, M.; Boucher, I.D.; De Miranda, S.; Deneuville, E.; Dubus, J.; Durieu, I.; Epaud, R.; Gerardin, M.; Grenet, D.; Houdouin, V.; Huet, F.; Reem, K.; Kessler, R.; Languepin, J.; Laurans, M.; Leroy, S.; Llerena, C.; Macey, J.; Mankikian, J.; Marguet, C.; Martin, C.; Mely, L.; Mittaine, M.; Murris-Espin, M.; Perisson, C.; Prevotat, A.; Ramel, S.; Rames, C.; Reix, P.; Revillon, M.; Reynaud-Gaubert, M.; Richaud-Thiriez, B.; Rittie, J.; Scalbert-Dujardin, M.; Sermet-Gaudelus, I.; Storni, V.; Tatopoulos, A.; Thouvenin, G.; Troussier, F.; Weiss, L.; Wizla, N.; Behl, E.; Brinkmann, F.; Claßen, M.; Graepler-Mainka, U.; Griese, M.; Grübl, A.; Hammermann, J.; Hebestreit, H.; Heinzmann, A.; Herz, A.; Kiefer, A.; Kinder, B.; Köster, H.; Kuhnert, S.; Mainz, J.; Mayer, A.; Naehrig, S.; Niehues, T.; Nüßlein, T.; Poplawska, K.; Ringshausen, F.; Rose, M.; Rosenecker, J.; Ruppel, R.; Scharschinger, A.; Schropp, C.; Schwarz, C.; Smaczny, C.; Sommerburg, O.; Sutharsan, S.; Stolz, S.; Thomas, W.; Wege, S.; Welzenbach, B.; Wollschläger, B.; Diamantea, F.; Hatziagorou, E.; Manika, K.; Cox, D.; Elnazir, B.; Fletcher, G.; Gunaratnam, C.; Mckone, E.F.; Plant, B.J.; Cohen-Cymberknoh, M.; Gur, M.; Livnat, G.; Mei-Zahav, M.; Amato, A.; Ferrari, G.; Badolato, R.; Poli, P.; Battistini, F.; Donati, V.; Bignamini, E.; Folino, A.; Carnovale, V.; Castellani, C.; Casciaro, R.; Cimino, G.; Cipolli, M.; Lucca, F.; Collura, M.; Ficili, F.; Daccò, V.; Gagliano, V.; Pizzamiglio, G.; Mencarini, V.; Palladino, N.; Leonardi, S.; Rotolo, N.; Lucanto, M.C.; Quattromano, E.; Lucidi, V.; Majo, F.; Alghisi, F.; Ciciriello, F.; Manca, A.; Leonetti, G.; Maschio, M.; Messore, B.; Pantano, S.; Pisi, G.; Spaggiari, C.; Raia, V.; Laezza, C.; Ros, M.; Salvatore, D.; Taccetti, G.; Francalanci, M.; Vitullo, P.; Zolin, A.; Aleksejeva, E.; Malakauskas, K.; Misevičiene, V.; Charatsi, A.; la Barrière, H.D.; Altenburg, J.; Bannier, M.; Heijerman, H.; Janssens, H.; Koppelman, G.; van der Meer, R.; Merkus, P.; Nuijsink, M.; Terheggen, S.; van der Vaart, H.; Wesseling, G.; de Winter, K.; Danevska, I.A.; Maretti, T.J.; Fustik, S.; Dziecichowicz-Latała, D.; Wojsyk-Banaszak, I.; Wozniacki, L.; Amorim, A.; Santos, A.S.A.; Castanhinha, S.; Gamboa, F.; Silva, T.R.; Gonçalves, F.; Pereira, L.; Ciuca, I.; Silva, S.; Csilla-Enikö, S.; Stan, I.; Amelina, E.; Boitсova, E.; Chernyavskaya, A.; Gorinova, Y.; Krasovskiy, S.; Mukhina, M.; Sherman, V.; Simonova, O.; Kondratyeva, E.; Bérešová, E.; Bližnáková, N.; Kayserová, H.; Salobir, B.; Šelb, J.; Krivec, U.; Fernandez, A.J.A.; Fernàndez, A.A.; García, F.B.; Aparicio, M.B.; Corullón, S.C.; Cortell-Aznar, I.; Pérez, I.; Colomer, J.C.I.; Roig, M.C.; Pecellín, I.D.; Cáceres, L.D.; Paredes, C.L.; Gartner, S.; Martínez, J.R.G.; Labarga, I.H.; Girón-Moreno, R.M.; Nogueira, E.J.; Ferreiro, A.L.; Neyra, A.L.; Castro, E.B.; Galarraga, L.M.; de Vincente, C.M.; Navarro, S.M.; Nieto-Royo, R.; Fuster, C.O.; Pastor, M.D.; Pérez-Ruiz, E.; Prados-Sánchez, C.; Cancelo, I.R.; de Valbuena, M.R.; Asensi, J.R.V.; Santiago, V.S.; García, P.F.; Tawfeeq, R.M.; Banki, A.; Gilljam, M.; Krantz, C.; Lindberg, U.; Lindblad, A.; Clarenbach, C.; Steinack, C.; Hage, R.; Schuurmans, M.; Fischer, R.; Kusche, R.; Rochat, I.; Schuurmans, M.; Walter, A.; Kamalaporn, H.; Hamouda, S.; Tural, D.A.; Ozcelik, U.; Asfuroğlu, P.; Eyüboğlu, T.Ş.; Aslan, A.T.; Bingöl, A.; Çobanoğlu, N.; Ozcan, G.; Dogru, D.; Gökdemir, Y.; Köse, M.; Pekcan, S.; Cosgriff, R.

doi:10.1016/j.jcf.2024.07.019

Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF). Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV1) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV1 and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection. Results: A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV1 pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection. Conclusions: No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.

Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study / J. Semenchuk, Y. Naito, S.C. Charman, S.B. Carr, S.Y. Cheng, B.C. Marshall, A. Faro, A. Elbert, H.H. Gutierrez, C.H. Goss, B. Karadag, P. Burgel, C. Colombo, M. Salvatore, R. Padoan, G. Daneau, S. Harutyunyan, N. Kashirskaya, L. Kirwan, P.G. Middleton, R. Ruseckaite, I. de Monestrol, L. Naehrlich, P. Mondejar-Lopez, A. Jung, J. van Rens, E. Bakkeheim, A. Orenti, D. Zomer-van Ommen, L.V.R. da Silva-Filho, F.F. Fernandes, M. Zampoli, A.L. Stephenson, I. Kasmi, O. Drali, S. Burghart, A. Lakatos-Krepcik, J. Eder, P. Jaksch, K. Kainz, M. Kallinger, A. Leitner, M. Mozdzen, A. Pfleger, S. Renner, M. Stadlinger, C. Thir, E. Nuriyev, H. Boboli, E. De Wachter, L. Dupont, S. Gohy, L. Hanssens, C. Knoop, E. Lammertyn, V. Nowé, J. Pirson, M. Thimmesch, E. Van Braeckel, K. Van Hoorenbeeck, E. Vanderhelst, E.P. Filho, R.A. Athanazio, V.D.C. Martins, M.C. Duarte, L.D.F.V. Monte, M.B. de Fuccio, A.D.S.C. Knabben, R. Melloti, D.G. Meneses, G. Petrova, D. Tješić-Drinković, A.V. Dugac, I. Bambir, P. Yiallouros, A. Bilkova, P. Drevinek, M. Macek, H.V. Olesen, T. Pressler, E.M. Fouda, S. Nasr, A.Y. Weldetsadik, M. Al-iede, O. Abdrakhmanov, H. Corvol, L. Lemonnier-Videau, M. Abely, C.B. Piccini, C. Belleguic, T. Bihouee, Y. Billon, S. Bui, B. Camara, M. Cheraud, R. Chiron, E.C. Duet, L. Cosson, M. Dalphin, I.D. Boucher, S. De Miranda, E. Deneuville, J. Dubus, I. Durieu, R. Epaud, M. Gerardin, D. Grenet, V. Houdouin, F. Huet, K. Reem, R. Kessler, J. Languepin, M. Laurans, S. Leroy, C. Llerena, J. Macey, J. Mankikian, C. Marguet, C. Martin, L. Mely, M. Mittaine, M. Murris-Espin, C. Perisson, A. Prevotat, S. Ramel, C. Rames, P. Reix, M. Revillon, M. Reynaud-Gaubert, B. Richaud-Thiriez, J. Rittie, M. Scalbert-Dujardin, I. Sermet-Gaudelus, V. Storni, A. Tatopoulos, G. Thouvenin, F. Troussier, L. Weiss, N. Wizla, E. Behl, F. Brinkmann, M. Claßen, U. Graepler-Mainka, M. Griese, A. Grübl, J. Hammermann, H. Hebestreit, A. Heinzmann, A. Herz, A. Kiefer, B. Kinder, H. Köster, S. Kuhnert, J. Mainz, A. Mayer, S. Naehrig, T. Niehues, T. Nüßlein, K. Poplawska, F. Ringshausen, M. Rose, J. Rosenecker, R. Ruppel, A. Scharschinger, C. Schropp, C. Schwarz, C. Smaczny, O. Sommerburg, S. Sutharsan, S. Stolz, W. Thomas, S. Wege, B. Welzenbach, B. Wollschläger, F. Diamantea, E. Hatziagorou, K. Manika, D. Cox, B. Elnazir, G. Fletcher, C. Gunaratnam, E.F. Mckone, B.J. Plant, M. Cohen-Cymberknoh, M. Gur, G. Livnat, M. Mei-Zahav, A. Amato, G. Ferrari, R. Badolato, P. Poli, F. Battistini, V. Donati, E. Bignamini, A. Folino, V. Carnovale, C. Castellani, R. Casciaro, G. Cimino, M. Cipolli, F. Lucca, M. Collura, F. Ficili, V. Daccò, V. Gagliano, G. Pizzamiglio, V. Mencarini, N. Palladino, S. Leonardi, N. Rotolo, M.C. Lucanto, E. Quattromano, V. Lucidi, F. Majo, F. Alghisi, F. Ciciriello, A. Manca, G. Leonetti, M. Maschio, B. Messore, S. Pantano, G. Pisi, C. Spaggiari, V. Raia, C. Laezza, M. Ros, D. Salvatore, G. Taccetti, M. Francalanci, P. Vitullo, A. Zolin, E. Aleksejeva, K. Malakauskas, V. Misevičiene, A. Charatsi, H.D. la Barrière, J. Altenburg, M. Bannier, H. Heijerman, H. Janssens, G. Koppelman, R. van der Meer, P. Merkus, M. Nuijsink, S. Terheggen, H. van der Vaart, G. Wesseling, K. de Winter, I.A. Danevska, T.J. Maretti, S. Fustik, D. Dziecichowicz-Latała, I. Wojsyk-Banaszak, L. Wozniacki, A. Amorim, A.S.A. Santos, S. Castanhinha, F. Gamboa, T.R. Silva, F. Gonçalves, L. Pereira, I. Ciuca, S. Silva, S. Csilla-Enikö, I. Stan, E. Amelina, E. Boitсova, A. Chernyavskaya, Y. Gorinova, S. Krasovskiy, M. Mukhina, V. Sherman, O. Simonova, E. Kondratyeva, E. Bérešová, N. Bližnáková, H. Kayserová, B. Salobir, J. Šelb, U. Krivec, A.J.A. Fernandez, A.A. Fernàndez, F.B. García, M.B. Aparicio, S.C. Corullón, I. Cortell-Aznar, I. Pérez, J.C.I. Colomer, M.C. Roig, I.D. Pecellín, L.D. Cáceres, C.L. Paredes, S. Gartner, J.R.G. Martínez, I.H. Labarga, R.M. Girón-Moreno, E.J. Nogueira, A.L. Ferreiro, A.L. Neyra, E.B. Castro, L.M. Galarraga, C.M. de Vincente, S.M. Navarro, R. Nieto-Royo, C.O. Fuster, M.D. Pastor, E. Pérez-Ruiz, C. Prados-Sánchez, I.R. Cancelo, M.R. de Valbuena, J.R.V. Asensi, V.S. Santiago, P.F. García, R.M. Tawfeeq, A. Banki, M. Gilljam, C. Krantz, U. Lindberg, A. Lindblad, C. Clarenbach, C. Steinack, R. Hage, M. Schuurmans, R. Fischer, R. Kusche, I. Rochat, M. Schuurmans, A. Walter, H. Kamalaporn, S. Hamouda, D.A. Tural, U. Ozcelik, P. Asfuroğlu, T.Ş. Eyüboğlu, A.T. Aslan, A. Bingöl, N. Çobanoğlu, G. Ozcan, D. Dogru, Y. Gökdemir, M. Köse, S. Pekcan, R. Cosgriff. - In: JOURNAL OF CYSTIC FIBROSIS. - ISSN 1569-1993. - (2024), pp. 1-8. [Epub ahead of print] [10.1016/j.jcf.2024.07.019]