The aims of this study is to evaluate the association between angiotensin-converting enzyme inhibitor (ACE-I), angiotensin II receptor blocker (ARBs) and/or statin use with the risk of pneumonia, as well as and with in-hospital and short-term outpatient mortality in hospitalized older patients with pneumonia. Patients aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro Politerapuie SIMI-Società Italiana di Medicina Interna) register from 2010 to 2019 were screened to assess the diagnosis of pneumonia and classified on whether or not they were prescribed with at least one drug among ACE-I, ARBs, and/or statins. Further study outcomes were mortality during hospital stay and at 3 months after hospital discharge. Among 5717 cases included (of whom 18.0% with pneumonia), 2915 (51.0%) were prescribed at least one drug among ACE-I, ARBs, and statins. An inverse association was found between treatment with ACE-I or ARBs and pneumonia (OR = 0.79, 95% CI 0.65-0.95). A higher effect was found among patients treated with ACE-I or ARBs in combination with statins (OR = 0.67, 95% CI 0.52-0.85). This study confirmed in the real-world setting that these largely used medications may reduce the risk of pneumonia in older people, who chronically take them for cardiovascular conditions.

Statins, ACE/ARBs drug use, and risk of pneumonia in hospitalized older patients: a retrospective cohort study / C. Franchi, R. Rossio, S. Mandelli, I. Ardoino, A. Nobili, F. Peyvandi, P.M. Mannucci, P.M. Mannucci, A. Nobili, G. Sesti, A. Pietrangelo, F. Perticone, F. Violi, S. Corrao, A. Marengoni, M. Tettamanti, L. Pasina, A. Novella, G. Miglio, A.A. Galbussera, I. Ardoino, S. Cantiero, D. Prisco, E. Silvestri, G. Emmi, A. Bettiol, I. Mattioli, M. Mazzetti, G. Biolo, M. Zanetti, G. Bartelloni, M. Zaccari, M. Chiuch, I. Martini, M. Pirro, G. Lupattelli, V. Bianconi, R. Alcidi, A. Giotta, M.R. Mannarino, D. Girelli, F. Busti, G. Marchi, M. Barbagallo, L. Dominguez, V. Beneduce, F. Cacioppo, G. Natoli, S. Mularo, M. Raspanti, C. Argano, F. Cavallaro, M. Zoli, M.L. Matacena, G. Orio, E. Magnolfi, G. Serafini, M. Brunori, I. Lazzari, A. Simili, M.D. Cappellini, G. Fabio, M.M.D. Amicis, G. De Luca, N. Scaramellini, V. Di Stefano, S. Leoni, S. Seghezzi, A.D.D. Mauro, D. Maira, M. Mancarella, T. Lucchi, P.D. Rossi, M. Clerici, S. Leoni, G. Bonini, F. Conti, S. Prolo, M. Fabrizi, M. Martelengo, G. Vigani, P. Nicolini, A. Di Sabatino, E. Miceli, M.V. Lenti, M. Pisati, L. Pitotti, V. Antoci, G. Cambiè, L. Pitotti, V. Antoci, R. Pontremoli, G. Murialdo, V. Beccati, G. Nobili, G. Leoncini, J. Alberto, F. Cattaneo, L. Anastasio, L. Sofia, M. Carbone, F. Cipollone, M.T. Guagnano, I. Rossi, E. Valeriani, D. D'Ardes, A. Cipollone, L. Esposito, S. Sestili, E. Angelucci, R.M. Ricciardi, G. Mancuso, D. Calipari, M. Bartone, R. Manetti, M. Sircana, M. Berria, A. Delitala, M. Muscaritoli, A. Molfino, E. Petrillo, A. Giorgi, C. Gracin, G. Imbimbo, G. Romanelli, A. Volpini, D. Lucente, F. Manzoni, A. Pirozzi, A. Zucchelli, T. Geneletti, E. Carlotti, A. Picardi, U.V. Gentilucci, P.G. Violi, G. Bellelli, M. Corsi, C. Antonucci, C. Sidoli, G. Principato, A. Bonfanti, H. Szabo, P. Mazzola, A. Piazzoli, M. Corsi, V. Lavinia, S. Armida, F. Arturi, E. Succurro, M. Melina, B. Tassone, F. Giofrè, F. Cosentino, D. Chiarello, F. Andreozzi, M.G. Serra, M.A. Bleve, A.B.T.D. Falco, E. Negro, M. Brenna, L. Trotta, G.L. Squintani, M.L. Randi, F. Fabris, I. Bertozzi, G. Bogoni, M.V. Rabuini, T. Prandini, F. Ratti, C. Zurlo, L. Cerruti, E. Cosi, S.A. Malerba, E. Reni, R. Manfredini, B. Boari, A. De Giorgi, R. Tiseo, G.M. Viglione, C. Savriè, G. Paolisso, M.R. Rizzo, C. Catalano, I. Di Meo, C. Borghi, E. Strocchi, E. Ianniello, M. Soldati, S. Schiavone, A. Bragagni, F.G. Leoni, V. De Sando, S. Scarduelli, M. Cammarosano, I. Pareo, E. Ianniello, F.G. Leoni, S. Scarduelli, C. Sabbà, F.S. Vella, P. Suppressa, G.M. De Vincenzo, A. Comitangelo, E. Amoruso, C. Custodero, G. Re, C.M. Palmisano, I. Barnaba, A. Schilardi, L. Fenoglio, A. Falcetta, A.V. Giraudo, S. D'Agnano, A.L. Fracanzani, S. Tiraboschi, A. Cespiati, G. Oberti, G. Sigon, F. Cinque, L. Colavolpe, J. Currà, F. Alletto, N. Scaramellini, S. Leoni, A.D. Di Mauro, G. Benzoni, F. Peyvandi, R. Rossio, G. Colombo, P. Agosti, E. Pagliaro, E. Semproni, C. Canetta, V. Monzani, V. Savojardo, G. Ceriani, C. Folli, F. Montecucco, L. Ottonello, L. Caserza, G. Vischi, S. Kassem, L. Liberale, G. Vischi, B. Saccomanno, C. Olivero, N.L. Liberato, T. Tognin, F. Purrello, A. Di Pino, S. Piro, M. Di Marco, R. Rozzini, L. Falanga, M.S. Pisciotta, F.B. Bellucci, S. Boffelli, C. Ferrandina, F. Mazzeo, E. Spazzini, G. Cono, G. Cesaroni, G. Montrucchio, P. Peasso, E. Favale, C. Poletto, C. Margaria, M. Sanino, L. Perri, L. Guasti, F. Rotunno, L. Castiglioni, A. Maresca, A. Squizzato, L. Campiotti, A. Grossi, R.D. Diprizio, F. Dentali, V. Behnke, M. Bertolotti, C. Mussi, G. Lancellotti, L. Orlandi, F. D'Imprima, A. Sciacqua, M. Perticone, R. Maio, A. Scozzafava, V. Condoleo, E. Clausi, G. Armentaro, A. Panza, V. Condoleo, V. Stanghellini, E. Ruggeri, S. Vecchio, I. Benzoni, G. Moroncini, W. Capeci, M. Mattioli, G.P. Martino, L. Biondi, P. Pettinari, M. Ormas, E. Filippini, D. Benfaremo, R. Romiti, S. Minisola, L. Colangelo, M. Cilli, G. Labbadia, J. Pepe, P. Castellino, L. Zanoli, A. Gaudio, A. Xourafa, C. Spichetti, S. Torre, A. Gennaro, G. Moreo, S. Prolo, G. Pina, A. Ballestrero, F. Ferrando, R. Gonella, D. Cerminara, P. Setti, C. Traversa, C. Scarsi, A.L. Patti, G. Famularo, P. Tarsitani, T. Morretti, A. Aglitti, M.G.M.G.P. Ceda, S. Morganti, A. Artoni, M. Grossi, C. Cattabiani, M. Salvi, F. Lauretani, R. Federici, S. Del Giacco, D. Firinu, G. Costanzo, A.G. Ledda, S. Chessa, G. Montalto, A. Licata, F.A. Montalto, A. Rizzo, F. Corica, G. Basile, A. Catalano, F. Bellone, C. Principato, A. Cocuzza, L. Malatino, B. Stancanelli, V. Terranova, S. Di Marca, R. Di Quattro, L. La Malfa, R. Caruso, I. Isaia, F. Castelletti, M. Regolo, C. Salmeri, N. Cardaci, P. Mecocci, C. Ruggiero, V. Boccardi, T. Meschi, A. Ticinesi, A. Nouvenne, P. Minuz, L. Fondrieschi, G.N. Imperiale, S. Morellini, A. Sartorio, M. Pirisi, G.P. Fra, D. Sola, M. Bellan, R. Quadri, E. Larovere, M. Novelli, E. Simeone, R. Scurti, F. Tolloso, R. Tarquini, A. Valoriani, S. Dolenti, G. Vannini, R. Volpi, P. Bocchi, A. Vignali, S. Harari, C. Lonati, F. Napoli, I. Aiello, F. Purrello, A. Di Pino, T. Salvatore, L. Monaco, C. Ricozzi, F. Coviello, C. Catalini, A. Pilotto, I. Indiano, F. Gandolfo, D. Gonella, F.L. Pasini, P.L. Capecchi, R. Nuti, R. Valenti, M. Ruvio, S. Cappelli, A. Palazzuoli, M. Bernardi, S.L. Bassi, L. Santi, G. Zaccherini, V. Durante, D. Tirotta, G. Eusebi, M. Cattaneo, M.V. Amoruso, P. Fracasso, C. Fasolino, M. Tresoldi, E. Bozzolo, S. Damanti, G. Deonette, M. Porta, M. Gino, S.M. di Cella, B. Pari, E. Pace, N. Null. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 19:3(2024 Apr), pp. 689-696. [10.1007/s11739-023-03528-w]

Statins, ACE/ARBs drug use, and risk of pneumonia in hospitalized older patients: a retrospective cohort study

C. Franchi
Primo
;
F. Peyvandi;N. Scaramellini
Membro del Collaboration Group
;
S. Leoni
Membro del Collaboration Group
;
S. Leoni
Membro del Collaboration Group
;
M. Fabrizi
Membro del Collaboration Group
;
M. Martelengo
Membro del Collaboration Group
;
G. Vigani
Membro del Collaboration Group
;
E. Negro
Membro del Collaboration Group
;
M. Brenna
Membro del Collaboration Group
;
G.L. Squintani
Membro del Collaboration Group
;
A.L. Fracanzani
Membro del Collaboration Group
;
A. Cespiati
Membro del Collaboration Group
;
F. Cinque
Membro del Collaboration Group
;
L. Colavolpe
Membro del Collaboration Group
;
F. Alletto
Membro del Collaboration Group
;
N. Scaramellini
Membro del Collaboration Group
;
S. Leoni
Membro del Collaboration Group
;
A.D. Di Mauro
Membro del Collaboration Group
;
G. Benzoni
Membro del Collaboration Group
;
F. Peyvandi
Membro del Collaboration Group
;
P. Agosti
Membro del Collaboration Group
;
E. Pagliaro;E. Semproni;S. Harari;
2024

Abstract

The aims of this study is to evaluate the association between angiotensin-converting enzyme inhibitor (ACE-I), angiotensin II receptor blocker (ARBs) and/or statin use with the risk of pneumonia, as well as and with in-hospital and short-term outpatient mortality in hospitalized older patients with pneumonia. Patients aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro Politerapuie SIMI-Società Italiana di Medicina Interna) register from 2010 to 2019 were screened to assess the diagnosis of pneumonia and classified on whether or not they were prescribed with at least one drug among ACE-I, ARBs, and/or statins. Further study outcomes were mortality during hospital stay and at 3 months after hospital discharge. Among 5717 cases included (of whom 18.0% with pneumonia), 2915 (51.0%) were prescribed at least one drug among ACE-I, ARBs, and statins. An inverse association was found between treatment with ACE-I or ARBs and pneumonia (OR = 0.79, 95% CI 0.65-0.95). A higher effect was found among patients treated with ACE-I or ARBs in combination with statins (OR = 0.67, 95% CI 0.52-0.85). This study confirmed in the real-world setting that these largely used medications may reduce the risk of pneumonia in older people, who chronically take them for cardiovascular conditions.
ACE inhibitors; ARBs; Older people; Pneumonia; Statins
Settore MED/09 - Medicina Interna
apr-2024
14-feb-2024
Article (author)
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