For years, scientists investigating amyloid precursor protein (APP) have focused on its pathogenetic role in the brains of Alzheimer's disease patients. Now, a study by Caille et al. adds new sites of action and new physiological functions for APP. They show that there are binding sites for secreted N-terminal nonamyloidogenic APP (sAPP) on epidermal growth factor (EGF)-responsive neural stem cells in the subventricular zone of the adult brain, where sAPP acts as an EGF cofactor to stimulate proliferation of these cells. This result opens the hypothesis that changes in the levels of sAPP could influence activity of the neurogenic regions of the adult brain in normal and pathological conditions.

Controlling neural stem cell division within the adult subventricular zone: an APPealing job / L. Conti, E. Cattaneo. - In: TRENDS IN NEUROSCIENCES. - ISSN 0166-2236. - 2005:2(2005 Feb), pp. 57-59.

Controlling neural stem cell division within the adult subventricular zone: an APPealing job

L. Conti
Primo
;
E. Cattaneo
Ultimo
2005

Abstract

For years, scientists investigating amyloid precursor protein (APP) have focused on its pathogenetic role in the brains of Alzheimer's disease patients. Now, a study by Caille et al. adds new sites of action and new physiological functions for APP. They show that there are binding sites for secreted N-terminal nonamyloidogenic APP (sAPP) on epidermal growth factor (EGF)-responsive neural stem cells in the subventricular zone of the adult brain, where sAPP acts as an EGF cofactor to stimulate proliferation of these cells. This result opens the hypothesis that changes in the levels of sAPP could influence activity of the neurogenic regions of the adult brain in normal and pathological conditions.
Neural stem cells, Adult brain, neurodegenerative disease, Amyloid Precursor Protein, Alzheimer's Disease
Settore BIO/14 - Farmacologia
feb-2005
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/10435
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