Synthesis of indole-fused 1,4-diazepinones through photocatalytic strategies

Over the last years, photoredox catalysis has spread as an essential tool to generate radicals under mild and selective conditions and it was applied for the synthesis of heterocyclic structures via cascade cyclizations (10.1021/acs.chemrev.0c00030). Considering this background and the interest of our group in the synthesis of polycyclic indoles, we developed a synthesis of indole-fused 1,4-diazepinones through a cascade radical addition on the C–C double bond of N-indolyl phenylacrylamides, followed by cyclization at indole C2-position (10.1002/adsc.202300708).