Extranodal NK/T-cell lymphoma (ENKTL) is a rare lymphoma subtype associated with Epstein-Barr virus (EBV) infection, portending a poor prognosis despite systemic chemotherapy. We present the unusual case of an 85-year-old man receiving ibrutinib for mantle cell lymphoma, who developed a erythematous, subcutaneous nodule on the forehead, featuring a proliferation of pleomorphic CD8 + /CD56 - /EBV + cells. Given the negative staging and comorbidities, a watchful waiting strategy was performed, experiencing a benign course with self-resolution and complete remission over a 4-year follow-up. The literature on primary cutaneous ENKTL has been discussed, with particular attention to clinical and histological prognostic factors.
Wait and see: a case of EBV + cutaneous extranodal NK/T-type lymphoma with indolent behaviour / I.F. Aromolo, C. Pescia, D. Simeoli, S.A. Violetti, V. Ferla, F.G. Rossi, G.A. Croci. - In: VIRCHOWS ARCHIV. - ISSN 0945-6317. - (2023). [Epub ahead of print] [10.1007/s00428-023-03681-9]
Wait and see: a case of EBV + cutaneous extranodal NK/T-type lymphoma with indolent behaviour
I.F. Aromolo
Primo
;C. PesciaSecondo
;D. Simeoli;S.A. Violetti;V. Ferla;F.G. RossiPenultimo
;G.A. CrociUltimo
2023
Abstract
Extranodal NK/T-cell lymphoma (ENKTL) is a rare lymphoma subtype associated with Epstein-Barr virus (EBV) infection, portending a poor prognosis despite systemic chemotherapy. We present the unusual case of an 85-year-old man receiving ibrutinib for mantle cell lymphoma, who developed a erythematous, subcutaneous nodule on the forehead, featuring a proliferation of pleomorphic CD8 + /CD56 - /EBV + cells. Given the negative staging and comorbidities, a watchful waiting strategy was performed, experiencing a benign course with self-resolution and complete remission over a 4-year follow-up. The literature on primary cutaneous ENKTL has been discussed, with particular attention to clinical and histological prognostic factors.File | Dimensione | Formato | |
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