Mechanical asphyxia (MA) is one of the causes of deaths that ultimately brings to cardiac arrest (CA), with high occurrence and dead rates (Zhang et al., 2021). Up to date, the diagnosis of an asphyxiated death is still based on cross comparisons between histological examinations and other circumstances, but the findings might be non-specific or, in some cases, totally absent. Moreover, the discrimination between a primitive CA or a CA after asphyxiation depends on factors that lack objective evidence (Locci et al., 2021). Considering that biochemical pathway alterations occur in a hypoxic environment, metabolomics, the latest “omic” technology, has caught attention to improve our understanding of asphyxia (Fattuoni et al., 2015) by detecting potential and useful biomarkers for asphyxiated bodies.
Metabolomic profiling in asphyxia: a promising tool / S. Casati, M. Dei Cas, L. Milotta, C. Ottaviano, M. Minoli, I. Angeli, C. Lammi, G. Roda, A. Battistini. ((Intervento presentato al convegno La Tossicologia Forense nella società contemporanea: dalla ricerca alle applicazioni : Congresso Nazionale GTFI : 12-13 maggio tenutosi a Roma nel 2023.
Metabolomic profiling in asphyxia: a promising tool
S. CasatiPrimo
;M. Dei CasSecondo
;L. Milotta;M. Minoli;I. Angeli;C. Lammi;G. RodaPenultimo
;A. BattistiniUltimo
2023
Abstract
Mechanical asphyxia (MA) is one of the causes of deaths that ultimately brings to cardiac arrest (CA), with high occurrence and dead rates (Zhang et al., 2021). Up to date, the diagnosis of an asphyxiated death is still based on cross comparisons between histological examinations and other circumstances, but the findings might be non-specific or, in some cases, totally absent. Moreover, the discrimination between a primitive CA or a CA after asphyxiation depends on factors that lack objective evidence (Locci et al., 2021). Considering that biochemical pathway alterations occur in a hypoxic environment, metabolomics, the latest “omic” technology, has caught attention to improve our understanding of asphyxia (Fattuoni et al., 2015) by detecting potential and useful biomarkers for asphyxiated bodies.File | Dimensione | Formato | |
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