Purpose: To evaluate microvascular and neuronal changes over 3 years in patients with type 1/2 diabetes mellitus (DM1/DM2), good metabolic control and no signs of diabetic retinopathy (DR). Methods: In this prospective, longitudinal study, 20 DM1, 48 DM2 and 24 controls underwent macular OCT ant OCT-A at baseline and after 3 years. Following parameters were considered: thickness of the central macula (CMT), retinal nerve fiber layer (NFL), ganglion cell (GCL+/GCL++) complex; perfusion and vessel density (PD/VD) and fractal dimension (FD) at the superficial and deep capillary plexuses (SCP/DCP); choriocapillaris flow deficits (CC-FD); foveal avascular zone (FAZ) metrics. MATLAB and ImageJ were used for OCT-A scans analyses. Results: Mean HbA1c was 7.4 ± 0.8% in DM1 and 7.2 ± 0.8% in DM2 at baseline, with no change at 3 years. No eye developed DR. In longitudinal analyses, PD at SCP (p=0.03) and FAZ area and perimeter (p<0.0001) significantly increased in DM2 compared to other groups. No longitudinal changes occurred in OCT parameters. In comparisons within groups, DM2 had a significant thinning of GCL++ in the outer ring, decreased PD at DCP and CC-FD, an increase in FAZ perimeter and area in DCP; DM1 had an increase in FAZ perimeter in DCP (p<0.001 for all comparisons). Conclusion: Longitudinal data showed significant microvascular retinal changes in DM2. No changes were detected in neuronal parameters and in DM1. Longer and larger studies are needed to confirm these preliminary data.

Longitudinal microvascular and neuronal retinal evaluation in patients with diabetes mellitus type 1 and 2 and good glycemic control / S. Vujosevic, C. Toma, E. Villani, P. Nucci, M. Brambilla, E. Torti, F.L. Prof, S. De Cillà. - In: RETINA. - ISSN 0275-004X. - (2023). [Epub ahead of print] [10.1097/IAE.0000000000003880]

Longitudinal microvascular and neuronal retinal evaluation in patients with diabetes mellitus type 1 and 2 and good glycemic control

S. Vujosevic
Primo
;
E. Villani;P. Nucci;
2023

Abstract

Purpose: To evaluate microvascular and neuronal changes over 3 years in patients with type 1/2 diabetes mellitus (DM1/DM2), good metabolic control and no signs of diabetic retinopathy (DR). Methods: In this prospective, longitudinal study, 20 DM1, 48 DM2 and 24 controls underwent macular OCT ant OCT-A at baseline and after 3 years. Following parameters were considered: thickness of the central macula (CMT), retinal nerve fiber layer (NFL), ganglion cell (GCL+/GCL++) complex; perfusion and vessel density (PD/VD) and fractal dimension (FD) at the superficial and deep capillary plexuses (SCP/DCP); choriocapillaris flow deficits (CC-FD); foveal avascular zone (FAZ) metrics. MATLAB and ImageJ were used for OCT-A scans analyses. Results: Mean HbA1c was 7.4 ± 0.8% in DM1 and 7.2 ± 0.8% in DM2 at baseline, with no change at 3 years. No eye developed DR. In longitudinal analyses, PD at SCP (p=0.03) and FAZ area and perimeter (p<0.0001) significantly increased in DM2 compared to other groups. No longitudinal changes occurred in OCT parameters. In comparisons within groups, DM2 had a significant thinning of GCL++ in the outer ring, decreased PD at DCP and CC-FD, an increase in FAZ perimeter and area in DCP; DM1 had an increase in FAZ perimeter in DCP (p<0.001 for all comparisons). Conclusion: Longitudinal data showed significant microvascular retinal changes in DM2. No changes were detected in neuronal parameters and in DM1. Longer and larger studies are needed to confirm these preliminary data.
Settore MED/30 - Malattie Apparato Visivo
2023
27-giu-2023
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/997053
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