Epstein-Barr virus (EBV) has established lifelong infection in more than 90% of humanity. While infection is usually controlled by the immune system, the human host fails to completely eliminate the pathogen. Several herpesviral pro- teins are known to act as immunoevasins, preventing or reducing recognition of EBV-infected cells. Only recently were microRNAs of EBV identified to reduce im- mune recognition further. This Gem summarizes what we know about immuno- modulatory microRNAs of herpesviruses.
microRNAs of Epstein-Barr virus control innate and adaptive anti-viral immunity / M. Albanese, T. Tagawa, A. Buschle, W. Hammerschmidt. - In: JOURNAL OF VIROLOGY. - ISSN 1098-5514. - 91:16(2017), pp. e01667-16.1-e01667-16.6. [10.1128/JVI.01667-16]
microRNAs of Epstein-Barr virus control innate and adaptive anti-viral immunity
M. AlbanesePrimo
;
2017
Abstract
Epstein-Barr virus (EBV) has established lifelong infection in more than 90% of humanity. While infection is usually controlled by the immune system, the human host fails to completely eliminate the pathogen. Several herpesviral pro- teins are known to act as immunoevasins, preventing or reducing recognition of EBV-infected cells. Only recently were microRNAs of EBV identified to reduce im- mune recognition further. This Gem summarizes what we know about immuno- modulatory microRNAs of herpesviruses.
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