We describe the first gold(I)-catalysed intramolecular hydroarylation of alkynes for the straightforward synthesis of inherently chiral calix[4]arenes. This step- and atom-economical approach, which exploits a formal meta-functionalisation of the calix[4]arene macrocycle, is able to deliver an ample family of N-heterocyclic, chiral compounds in high yields and functional group tolerance.

Gold(I)-catalysed hydroarylations of alkynes for the synthesis of inherently chiral calix[4]arenes / G. Giovanardi, G. Scarica, V. Pirovano, A. Secchi, G. Cera. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 21:19(2023 May 17), pp. 4072-4083. [10.1039/D3OB00603D]

Gold(I)-catalysed hydroarylations of alkynes for the synthesis of inherently chiral calix[4]arenes

V. Pirovano;
2023

Abstract

We describe the first gold(I)-catalysed intramolecular hydroarylation of alkynes for the straightforward synthesis of inherently chiral calix[4]arenes. This step- and atom-economical approach, which exploits a formal meta-functionalisation of the calix[4]arene macrocycle, is able to deliver an ample family of N-heterocyclic, chiral compounds in high yields and functional group tolerance.
Settore CHIM/06 - Chimica Organica
17-mag-2023
27-apr-2023
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/969810
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