We describe the first gold(I)-catalysed intramolecular hydroarylation of alkynes for the straightforward synthesis of inherently chiral calix[4]arenes. This step- and atom-economical approach, which exploits a formal meta-functionalisation of the calix[4]arene macrocycle, is able to deliver an ample family of N-heterocyclic, chiral compounds in high yields and functional group tolerance.
Gold(I)-catalysed hydroarylations of alkynes for the synthesis of inherently chiral calix[4]arenes / G. Giovanardi, G. Scarica, V. Pirovano, A. Secchi, G. Cera. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 21:19(2023 May 17), pp. 4072-4083. [10.1039/D3OB00603D]
Gold(I)-catalysed hydroarylations of alkynes for the synthesis of inherently chiral calix[4]arenes
V. Pirovano;
2023
Abstract
We describe the first gold(I)-catalysed intramolecular hydroarylation of alkynes for the straightforward synthesis of inherently chiral calix[4]arenes. This step- and atom-economical approach, which exploits a formal meta-functionalisation of the calix[4]arene macrocycle, is able to deliver an ample family of N-heterocyclic, chiral compounds in high yields and functional group tolerance.
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