Mycobacterium avium ssp. paratuberculosis (MAP), causes Johne's disease (JD), or paratuberculosis, a chronic enteritis of ruminants, which in goats is characterized by ileal lesions. The work described here is a case-control association study using the Illumina Caprine SNP50 BeadChip to unravel the genes involved in susceptibility of goats to JD. Goats in herds with a high occurrence of Johne's disease were classified as healthy or infected based on the level of serum antibodies against MAP, and 331 animals were selected for the association study. Goats belonged to the Jonica (157) and Siriana breeds (174). Whole-genome association analysis identified one region suggestive of significance associated with an antibody response to MAP on chromosome 7 (p-value = 1.23 x 10(-5)). These results provide evidence for genetic loci involved in the antibody response to MAP in goats.

Genome‐wide association study for antibody response to Mycobacterium avium ssp. paratubeculosis in goats / G. Minozzi, M.G. DE IORIO, F. Palazzo, G. Gandini, S. Biffani, G. Paolillo, E. Ciani, V. Di Marco Lo Presti, A. Stella, J.L. Williams. - In: ANIMAL GENETICS. - ISSN 1365-2052. - 54:1(2023), pp. 78-81. [10.1111/age.13271]

Genome‐wide association study for antibody response to Mycobacterium avium ssp. paratubeculosis in goats

G. Minozzi
Primo
Conceptualization
;
M.G. DE IORIO
Secondo
Investigation
;
G. Gandini
Writing – Review & Editing
;
G. Paolillo
Formal Analysis
;
2023

Abstract

Mycobacterium avium ssp. paratuberculosis (MAP), causes Johne's disease (JD), or paratuberculosis, a chronic enteritis of ruminants, which in goats is characterized by ileal lesions. The work described here is a case-control association study using the Illumina Caprine SNP50 BeadChip to unravel the genes involved in susceptibility of goats to JD. Goats in herds with a high occurrence of Johne's disease were classified as healthy or infected based on the level of serum antibodies against MAP, and 331 animals were selected for the association study. Goats belonged to the Jonica (157) and Siriana breeds (174). Whole-genome association analysis identified one region suggestive of significance associated with an antibody response to MAP on chromosome 7 (p-value = 1.23 x 10(-5)). These results provide evidence for genetic loci involved in the antibody response to MAP in goats.
ELISA; SNPs; caprine; genetic association; paratuberculosis
Settore AGR/17 - Zootecnica Generale e Miglioramento Genetico
2023
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/969505
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