Oxygen is a central molecule for numerous metabolic and cytophysiological processes, and, indeed, its imbalance can lead to numerous pathological consequences. In the human body, the brain is an aerobic organ and for this reason, it is very sensitive to oxygen equilibrium. The consequences of oxygen imbalance are especially devastating when occurring in this organ. Indeed, oxygen imbalance can lead to hypoxia, hyperoxia, protein misfolding, mitochondria dysfunction, alterations in heme metabolism and neuroinflammation. Consequently, these dysfunctions can cause numerous neurological alterations, both in the pediatric life and in the adult ages. These disorders share numerous common pathways, most of which are consequent to redox imbalance. In this review, we will focus on the dysfunctions present in neurodegenerative disorders (specifically Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis) and pediatric neurological disorders (X-adrenoleukodystrophies, spinal muscular atrophy, mucopolysaccharidoses and Pelizaeus-Merzbacher Disease), highlighting their underlining dysfunction in redox and identifying potential therapeutic strategies.

Redox Imbalance in Neurological Disorders in Adults and Children / F. Rey, C. Berardo, E. Maghraby, A. Mauri, L. Messa, L. Esposito, G. Casili, S. Ottolenghi, E. Bonaventura, S. Cuzzocrea, G. Zuccotti, D. Tonduti, E. Esposito, I. Paterniti, C. Cereda, S. Carelli. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 12:4(2023 Apr 20), pp. 965.1-965.34. [10.3390/antiox12040965]

Redox Imbalance in Neurological Disorders in Adults and Children

F. Rey
Primo
;
C. Berardo
Secondo
;
A. Mauri;L. Esposito;S. Ottolenghi;G. Zuccotti;D. Tonduti;E. Esposito;
2023

Abstract

Oxygen is a central molecule for numerous metabolic and cytophysiological processes, and, indeed, its imbalance can lead to numerous pathological consequences. In the human body, the brain is an aerobic organ and for this reason, it is very sensitive to oxygen equilibrium. The consequences of oxygen imbalance are especially devastating when occurring in this organ. Indeed, oxygen imbalance can lead to hypoxia, hyperoxia, protein misfolding, mitochondria dysfunction, alterations in heme metabolism and neuroinflammation. Consequently, these dysfunctions can cause numerous neurological alterations, both in the pediatric life and in the adult ages. These disorders share numerous common pathways, most of which are consequent to redox imbalance. In this review, we will focus on the dysfunctions present in neurodegenerative disorders (specifically Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis) and pediatric neurological disorders (X-adrenoleukodystrophies, spinal muscular atrophy, mucopolysaccharidoses and Pelizaeus-Merzbacher Disease), highlighting their underlining dysfunction in redox and identifying potential therapeutic strategies.
Alzheimer’s disease; Parkinson’s disease; Pelizaeus–Merzbacher disease; X-adrenoleukodystrophies; amyotrophic lateral sclerosis; mucopolysaccharidoses; neurodegenerative diseases; neurodevelopmental disorders; oxygen; redox; spinal muscular atrophy
Settore MED/39 - Neuropsichiatria Infantile
20-apr-2023
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/968557
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