Neuroactive steroids are crucial regulators of nervous functions. In the brain, progesterone, testosterone, and their metabolites exert their functions through complex regulation. In particular, the metabolism of these steroids and their subsequent interaction with different receptors orchestrate the fine-tuning of neuronal and glial functions. The key enzymes modulating progesterone and testosterone mechanism of action in the brain are here discussed.
Key players in progesterone and testosterone action: the metabolizing enzymes / S. Giatti, S. Diviccaro, R.C. Melcangi. - In: CURRENT OPINION IN ENDOCRINE AND METABOLIC RESEARCH. - ISSN 2451-9650. - 23:(2022 Apr), pp. 100319.1-100319.8. [10.1016/j.coemr.2022.100319]
Key players in progesterone and testosterone action: the metabolizing enzymes
S. Giatti
Primo
;S. DiviccaroPenultimo
;R.C. MelcangiUltimo
2022
Abstract
Neuroactive steroids are crucial regulators of nervous functions. In the brain, progesterone, testosterone, and their metabolites exert their functions through complex regulation. In particular, the metabolism of these steroids and their subsequent interaction with different receptors orchestrate the fine-tuning of neuronal and glial functions. The key enzymes modulating progesterone and testosterone mechanism of action in the brain are here discussed.
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