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Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Apoptotic cell death in disease-Current understanding of the NCCD 2023 / I. Vitale, F. Pietrocola, E. Guilbaud, S.A. Aaronson, J.M. Abrams, D. Adam, M. Agostini, P. Agostinis, E.S. Alnemri, L. Altucci, I. Amelio, D.W. Andrews, R.I. Aqeilan, E. Arama, E.H. Baehrecke, S. Balachandran, D. Bano, N.A. Barlev, J. Bartek, N.G. Bazan, C. Becker, F. Bernassola, M.J.M. Bertrand, M.E. Bianchi, M.V. Blagosklonny, J.M. Blander, G. Blandino, K. Blomgren, C. Borner, C.D. Bortner, P. Bove, P. Boya, C. Brenner, P. Broz, T. Brunner, R.B. Damgaard, G.A. Calin, M. Campanella, E. Candi, M. Carbone, D. Carmona-Gutierrez, F. Cecconi, F.K. Chan, G. Chen, Q. Chen, Y.H. Chen, E.H. Cheng, J.E. Chipuk, J.A. Cidlowski, A. Ciechanover, G. Ciliberto, M. Conrad, J.R. Cubillos-Ruiz, P.E. Czabotar, V. D'Angiolella, M. Daugaard, T.M. Dawson, V.L. Dawson, R. De Maria, B. De Strooper, K. Debatin, R.J. Deberardinis, A. Degterev, G. Del Sal, M. Deshmukh, F. Di Virgilio, M. Diederich, S.J. Dixon, B.D. Dynlacht, W.S. El-Deiry, J.W. Elrod, K. Engeland, G.M. Fimia, C. Galassi, C. Ganini, A.J. Garcia-Saez, A.D. Garg, C. Garrido, E. Gavathiotis, M. Gerlic, S. Ghosh, D.R. Green, L.A. Greene, H. Gronemeyer, G. Häcker, G. Hajnóczky, J.M. Hardwick, Y. Haupt, S. He, D.M. Heery, M.O. Hengartner, C. Hetz, D.A. Hildeman, H. Ichijo, S. Inoue, M. Jäättelä, A. Janic, B. Joseph, P.J. Jost, T. Kanneganti, M. Karin, H. Kashkar, T. Kaufmann, G.L. Kelly, O. Kepp, A. Kimchi, R.N. Kitsis, D.J. Klionsky, R. Kluck, D.V. Krysko, D. Kulms, S. Kumar, S. Lavandero, I.N. Lavrik, J.J. Lemasters, G. Liccardi, A. Linkermann, S.A. Lipton, R.A. Lockshin, C. López-Otín, T. Luedde, M. Macfarlane, F. Madeo, W. Malorni, G. Manic, R. Mantovani, S. Marchi, J. Marine, S.J. Martin, J. Martinou, P.G. Mastroberardino, J.P. Medema, P. Mehlen, P. Meier, G. Melino, S. Melino, E.A. Miao, U.M. Moll, C. Muñoz-Pinedo, D.J. Murphy, M.V. Niklison-Chirou, F. Novelli, G. Núñez, A. Oberst, D. Ofengeim, J.T. Opferman, M. Oren, M. Pagano, T. Panaretakis, M. Pasparakis, J.M. Penninger, F. Pentimalli, D.M. Pereira, S. Pervaiz, M.E. Peter, P. Pinton, G. Porta, J.H.M. Prehn, H. Puthalakath, G.A. Rabinovich, K. Rajalingam, K.S. Ravichandran, M. Rehm, J. Ricci, R. Rizzuto, N. Robinson, C.M.P. Rodrigues, B. Rotblat, C.V. Rothlin, D.C. Rubinsztein, T. Rudel, A. Rufini, K.M. Ryan, K.A. Sarosiek, A. Sawa, E. Sayan, K. Schroder, L. Scorrano, F. Sesti, F. Shao, Y. Shi, G.S. Sica, J. Silke, H. Simon, A. Sistigu, A. Stephanou, B.R. Stockwell, F. Strapazzon, A. Strasser, L. Sun, E. Sun, Q. Sun, G. Szabadkai, S.W.G. Tait, D. Tang, N. Tavernarakis, C.M. Troy, B. Turk, N. Urbano, P. Vandenabeele, T. Vanden Berghe, M.G. Vander Heiden, J.L. Vanderluit, A. Verkhratsky, A. Villunger, S. von Karstedt, A.K. Voss, K.H. Vousden, D. Vucic, D. Vuri, E.F. Wagner, H. Walczak, D. Wallach, R. Wang, Y. Wang, A. Weber, W. Wood, T. Yamazaki, H. Yang, Z. Zakeri, J.E. Zawacka-Pankau, L. Zhang, H. Zhang, B. Zhivotovsky, W. Zhou, M. Piacentini, G. Kroemer, L. Galluzzi. - In: CELL DEATH AND DIFFERENTIATION. - ISSN 1476-5403. - 30:5(2023 May), pp. 1097-1154. [10.1038/s41418-023-01153-w]

Apoptotic cell death in disease-Current understanding of the NCCD 2023

R. Mantovani;G. Porta;A. Rufini;
2023

Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.
Sì
English
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
Review essay
Comitato scientifico
Pubblicazione scientifica
Goal 3: Good health and well-being
mag-2023
26-apr-2023
Nature Publishing Group
30
5
1097
1154
58
Pubblicato
Periodico con rilevanza internazionale
pubmed
scopus
crossref
WOS:000992438100001
2-s2.0-85153609153
37100955
Aderisco
info:eu-repo/semantics/article
Apoptotic cell death in disease-Current understanding of the NCCD 2023 / I. Vitale, F. Pietrocola, E. Guilbaud, S.A. Aaronson, J.M. Abrams, D. Adam, M. Agostini, P. Agostinis, E.S. Alnemri, L. Altucci, I. Amelio, D.W. Andrews, R.I. Aqeilan, E. Arama, E.H. Baehrecke, S. Balachandran, D. Bano, N.A. Barlev, J. Bartek, N.G. Bazan, C. Becker, F. Bernassola, M.J.M. Bertrand, M.E. Bianchi, M.V. Blagosklonny, J.M. Blander, G. Blandino, K. Blomgren, C. Borner, C.D. Bortner, P. Bove, P. Boya, C. Brenner, P. Broz, T. Brunner, R.B. Damgaard, G.A. Calin, M. Campanella, E. Candi, M. Carbone, D. Carmona-Gutierrez, F. Cecconi, F.K. Chan, G. Chen, Q. Chen, Y.H. Chen, E.H. Cheng, J.E. Chipuk, J.A. Cidlowski, A. Ciechanover, G. Ciliberto, M. Conrad, J.R. Cubillos-Ruiz, P.E. Czabotar, V. D'Angiolella, M. Daugaard, T.M. Dawson, V.L. Dawson, R. De Maria, B. De Strooper, K. Debatin, R.J. Deberardinis, A. Degterev, G. Del Sal, M. Deshmukh, F. Di Virgilio, M. Diederich, S.J. Dixon, B.D. Dynlacht, W.S. El-Deiry, J.W. Elrod, K. Engeland, G.M. Fimia, C. Galassi, C. Ganini, A.J. Garcia-Saez, A.D. Garg, C. Garrido, E. Gavathiotis, M. Gerlic, S. Ghosh, D.R. Green, L.A. Greene, H. Gronemeyer, G. Häcker, G. Hajnóczky, J.M. Hardwick, Y. Haupt, S. He, D.M. Heery, M.O. Hengartner, C. Hetz, D.A. Hildeman, H. Ichijo, S. Inoue, M. Jäättelä, A. Janic, B. Joseph, P.J. Jost, T. Kanneganti, M. Karin, H. Kashkar, T. Kaufmann, G.L. Kelly, O. Kepp, A. Kimchi, R.N. Kitsis, D.J. Klionsky, R. Kluck, D.V. Krysko, D. Kulms, S. Kumar, S. Lavandero, I.N. Lavrik, J.J. Lemasters, G. Liccardi, A. Linkermann, S.A. Lipton, R.A. Lockshin, C. López-Otín, T. Luedde, M. Macfarlane, F. Madeo, W. Malorni, G. Manic, R. Mantovani, S. Marchi, J. Marine, S.J. Martin, J. Martinou, P.G. Mastroberardino, J.P. Medema, P. Mehlen, P. Meier, G. Melino, S. Melino, E.A. Miao, U.M. Moll, C. Muñoz-Pinedo, D.J. Murphy, M.V. Niklison-Chirou, F. Novelli, G. Núñez, A. Oberst, D. Ofengeim, J.T. Opferman, M. Oren, M. Pagano, T. Panaretakis, M. Pasparakis, J.M. Penninger, F. Pentimalli, D.M. Pereira, S. Pervaiz, M.E. Peter, P. Pinton, G. Porta, J.H.M. Prehn, H. Puthalakath, G.A. Rabinovich, K. Rajalingam, K.S. Ravichandran, M. Rehm, J. Ricci, R. Rizzuto, N. Robinson, C.M.P. Rodrigues, B. Rotblat, C.V. Rothlin, D.C. Rubinsztein, T. Rudel, A. Rufini, K.M. Ryan, K.A. Sarosiek, A. Sawa, E. Sayan, K. Schroder, L. Scorrano, F. Sesti, F. Shao, Y. Shi, G.S. Sica, J. Silke, H. Simon, A. Sistigu, A. Stephanou, B.R. Stockwell, F. Strapazzon, A. Strasser, L. Sun, E. Sun, Q. Sun, G. Szabadkai, S.W.G. Tait, D. Tang, N. Tavernarakis, C.M. Troy, B. Turk, N. Urbano, P. Vandenabeele, T. Vanden Berghe, M.G. Vander Heiden, J.L. Vanderluit, A. Verkhratsky, A. Villunger, S. von Karstedt, A.K. Voss, K.H. Vousden, D. Vucic, D. Vuri, E.F. Wagner, H. Walczak, D. Wallach, R. Wang, Y. Wang, A. Weber, W. Wood, T. Yamazaki, H. Yang, Z. Zakeri, J.E. Zawacka-Pankau, L. Zhang, H. Zhang, B. Zhivotovsky, W. Zhou, M. Piacentini, G. Kroemer, L. Galluzzi. - In: CELL DEATH AND DIFFERENTIATION. - ISSN 1476-5403. - 30:5(2023 May), pp. 1097-1154. [10.1038/s41418-023-01153-w]
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