The structure and properties of a group of gangliosides modified by mild alkaline treatment are discussed. We will present the occurrence and the structure of gangliosides carrying the N-acetyneuraminic acid O-acetylated in position 9, the Neu5,9Ac(2), and of gangliosides carrying a sialic acid that forms a lactone ring. Starting from biochemical data we will discuss the possible biochemical role played by these gangliosides in the processes of cell signaling and maintenance of brain functions.
Alkali-labile gangliosides / L. Mauri, S. Sonnino. - In: GLYCOCONJUGATE JOURNAL. - ISSN 0282-0080. - (2023). [Epub ahead of print] [10.1007/s10719-023-10103-0]
Alkali-labile gangliosides
L. Mauri
Primo
;S. Sonnino
Ultimo
2023
Abstract
The structure and properties of a group of gangliosides modified by mild alkaline treatment are discussed. We will present the occurrence and the structure of gangliosides carrying the N-acetyneuraminic acid O-acetylated in position 9, the Neu5,9Ac(2), and of gangliosides carrying a sialic acid that forms a lactone ring. Starting from biochemical data we will discuss the possible biochemical role played by these gangliosides in the processes of cell signaling and maintenance of brain functions.
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