Mitral valve prolapse (MVP) affects about 2-3% of the general population, mostly women, and is the most common cause of primary chronic mitral regurgitation (MR) in western countries. The natural history is heterogeneous and widely determined by the severity of MR. Although most patients remain asymptomatic with a near-normal life expectancy, approximately 5 to 10 % progress to severe MR. As largely recognized, left ventricular (LV) dysfunction due to chronic volume overload per se identifies a subgroup at risk of cardiac death. However, there is rising evidence of a link between MVP and life threating ventricular arrhythmias (VAs)/sudden cardiac death (SCD) in a small subset of middle-aged patients without significant MR, heart failure and remodeled hearts. The present review focuses on the underlying mechanism of electric instability and unexpected cardiac death in this subset of young patients, from the myocardial scarring of the LV infero-lateral wall due to mechanical stretch exerted by the prolapsing leaflets and mitral annular disjunction, to the inflammation's impact on fibrosis pathways along with a constitutional hyperadrenergic state. The heterogeneity of clinical course reveals a necessity of risk stratification, preferably through non-invasive multimodality imaging, that will help to identify and prevent adverse scenarios in young MVP patients.
Arrhythmogenic Mitral Valve Prolapse and Sudden Cardiac Death: an Update and Current Perspectives / V. Battaglia, G. Santangelo, F. Bursi, P. Simeoli, M. Guazzi. - In: CURRENT PROBLEMS IN CARDIOLOGY. - ISSN 0146-2806. - 48:7(2023 Mar 24), pp. 101724.1-101724.26. [10.1016/j.cpcardiol.2023.101724]
Arrhythmogenic Mitral Valve Prolapse and Sudden Cardiac Death: an Update and Current Perspectives
F. Bursi;P. SimeoliPenultimo
;M. GuazziUltimo
2023
Abstract
Mitral valve prolapse (MVP) affects about 2-3% of the general population, mostly women, and is the most common cause of primary chronic mitral regurgitation (MR) in western countries. The natural history is heterogeneous and widely determined by the severity of MR. Although most patients remain asymptomatic with a near-normal life expectancy, approximately 5 to 10 % progress to severe MR. As largely recognized, left ventricular (LV) dysfunction due to chronic volume overload per se identifies a subgroup at risk of cardiac death. However, there is rising evidence of a link between MVP and life threating ventricular arrhythmias (VAs)/sudden cardiac death (SCD) in a small subset of middle-aged patients without significant MR, heart failure and remodeled hearts. The present review focuses on the underlying mechanism of electric instability and unexpected cardiac death in this subset of young patients, from the myocardial scarring of the LV infero-lateral wall due to mechanical stretch exerted by the prolapsing leaflets and mitral annular disjunction, to the inflammation's impact on fibrosis pathways along with a constitutional hyperadrenergic state. The heterogeneity of clinical course reveals a necessity of risk stratification, preferably through non-invasive multimodality imaging, that will help to identify and prevent adverse scenarios in young MVP patients.File | Dimensione | Formato | |
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