Life and biological units are the result of the supramolecular arrangement of many different types of molecules, all of them combined with exquisite precision to achieve specific functions. Taking inspiration from the design principles of nature allows engineering more efficient and compatible biomaterials. Indeed, bionic (from bion-, unit of life and -ic, like) materials have gained increasing attention in the last decades due to their ability to mimic some of the characteristics of nature systems, such as dynamism, selectivity, or signalling. However, there are still many challenges when it comes to their interaction with the human body, which hinder their further clinical development. Here we review some of the recent progress in the field of molecular bionics with the final aim of providing with design rules to ensure their stability in biological media as well as to engineer novel functionalities which enable navigating the human body.

Molecular bionics – engineering biomaterials at the molecular level using biological principles / L. Rodriguez-Arco, A. Poma, L. Ruiz-Perez, E. Scarpa, K. Ngamkham, G. Battaglia. - In: BIOMATERIALS. - ISSN 0142-9612. - 192:(2019 Feb), pp. 26-50. [10.1016/j.biomaterials.2018.10.044]

Molecular bionics – engineering biomaterials at the molecular level using biological principles

E. Scarpa;
2019

Abstract

Life and biological units are the result of the supramolecular arrangement of many different types of molecules, all of them combined with exquisite precision to achieve specific functions. Taking inspiration from the design principles of nature allows engineering more efficient and compatible biomaterials. Indeed, bionic (from bion-, unit of life and -ic, like) materials have gained increasing attention in the last decades due to their ability to mimic some of the characteristics of nature systems, such as dynamism, selectivity, or signalling. However, there are still many challenges when it comes to their interaction with the human body, which hinder their further clinical development. Here we review some of the recent progress in the field of molecular bionics with the final aim of providing with design rules to ensure their stability in biological media as well as to engineer novel functionalities which enable navigating the human body.
Biomaterials; Biomedicine; Molecular bionics; Organic chemistry; Supramolecular chemistry; Topology;
Settore BIO/11 - Biologia Molecolare
Settore BIO/13 - Biologia Applicata
Settore BIO/14 - Farmacologia
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
feb-2019
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/964616
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