Metaplastic breast cancer (MpBC) is a rare and aggressive histologic subtype of breast cancer (BC) characterized by the presence of at least two cellular types, commonly epithelial and mesenchymal components. Despite growing evidence that MpBC is a unique entity, it has long been treated as a variant of nonspecial type (NST) BC. MpBC typically shows the phenotype of triple-negative breast cancer (TNBC), but compared to NST-TNBC, it is a relatively chemorefractory tumor associated with worse outcomes. Therefore, there is an urgent need to develop management guidelines specifically for MpBC to improve the prognosis of patients with early MpBC. This expert consensus aims to guide diagnosis and standardize clinical management of early MpBC among treating physicians. We provide guidance on the challenging radiological and pathological diagnosis of MpBC. Evidence on the involvement of genetic predisposition in the development of MpBC is also explored. We emphasize the importance of a multidisciplinary approach for the treatment of patients with early MpBC. The optimal surgery and radiotherapy approach is presented, as well as the opportunity offered by novel therapeutic approaches to increase treatment response in this chemoresistant subtype. Appropriate management of patients with MpBC is critical to reduce the high risk of local and distant recurrence that characterizes this disease.

Metaplastic breast cancer: an all-round multidisciplinary consensus / G. Corso, C. Criscitiello, L. Nicosia, F. Pesapane, E. Vicini, F. Magnoni, A. Sibilio, C. Zanzottera, A.M. De Scalzi, S. Mannucci, M. Marabelli, M. Calvello, I. Feroce, P. Zagami, F.M. Porta, A. Toesca, P. Tarantino, E. Nicolò, G. Mazzarol, C. La Vecchia, B. Bonanni, M.C. Leonardi, P. Veronesi, N. Fusco. - In: EUROPEAN JOURNAL OF CANCER PREVENTION. - ISSN 0959-8278. - (2023), pp. 1-16. [Epub ahead of print] [10.1097/CEJ.0000000000000794]

Metaplastic breast cancer: an all-round multidisciplinary consensus

G. Corso
Primo
;
C. Criscitiello
Secondo
;
L. Nicosia;F. Pesapane;M. Calvello;P. Zagami;F.M. Porta;C. La Vecchia;P. Veronesi
Penultimo
;
N. Fusco
Ultimo
2023

Abstract

Metaplastic breast cancer (MpBC) is a rare and aggressive histologic subtype of breast cancer (BC) characterized by the presence of at least two cellular types, commonly epithelial and mesenchymal components. Despite growing evidence that MpBC is a unique entity, it has long been treated as a variant of nonspecial type (NST) BC. MpBC typically shows the phenotype of triple-negative breast cancer (TNBC), but compared to NST-TNBC, it is a relatively chemorefractory tumor associated with worse outcomes. Therefore, there is an urgent need to develop management guidelines specifically for MpBC to improve the prognosis of patients with early MpBC. This expert consensus aims to guide diagnosis and standardize clinical management of early MpBC among treating physicians. We provide guidance on the challenging radiological and pathological diagnosis of MpBC. Evidence on the involvement of genetic predisposition in the development of MpBC is also explored. We emphasize the importance of a multidisciplinary approach for the treatment of patients with early MpBC. The optimal surgery and radiotherapy approach is presented, as well as the opportunity offered by novel therapeutic approaches to increase treatment response in this chemoresistant subtype. Appropriate management of patients with MpBC is critical to reduce the high risk of local and distant recurrence that characterizes this disease.
Settore MED/01 - Statistica Medica
Settore MED/06 - Oncologia Medica
Settore MED/42 - Igiene Generale e Applicata
2023
18-apr-2023
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/963396
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