We evaluated CD34(+) cells in a single-centre series of 49 consecutive patients with myelofibrosis (MF) at baseline and during ruxolitinib therapy and examined any association with spleen response. The median (range) absolute number of circulating CD34(+) cells was 0.0835 (0.001-1.528) x 10(9)/L at diagnosis, and 0.123 (0.002-1.528) x 10(9)/L at ruxolitinib start. With the exception of a transient increase after 3 months of ruxolitinib therapy, a progressive reduction in CD34(+) cells count was documented, down to a minimum of 0.063 x 10(9)/L after 36 months. We then assessed the association between spleen diameter expressed as the distance from the left costal margin (outcome) and log(CD34(+)) cells count using random-intercept and random slope multivariable regression models to take into account within subject correlation: after adjusting for time and ruxolitinib dosage, we estimated a 0.7 cm increase (95% confidence interval 0.2-1.2, p = 0.003) in spleen length for each unit increase in log(CD34(+)) cells count (x 10(9)/L). Although our study has some limitations, mainly related to its retrospective design, our approach may introduce a reproducible and simple tool that could facilitate the assessment of spleen response more objectively in patients with MF treated with ruxolitinib.

Trend of circulating CD34+ cells in patients with myelofibrosis: Association with spleen response during ruxolitinib treatment / A. Iurlo, N. Galli, C. Bucelli, S. Artuso, D. Consonni, D. Cattaneo. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - 200:3(2023 Feb), pp. 315-322. [10.1111/bjh.18526]

Trend of circulating CD34+ cells in patients with myelofibrosis: Association with spleen response during ruxolitinib treatment

N. Galli
Secondo
;
D. Cattaneo
Ultimo
2023

Abstract

We evaluated CD34(+) cells in a single-centre series of 49 consecutive patients with myelofibrosis (MF) at baseline and during ruxolitinib therapy and examined any association with spleen response. The median (range) absolute number of circulating CD34(+) cells was 0.0835 (0.001-1.528) x 10(9)/L at diagnosis, and 0.123 (0.002-1.528) x 10(9)/L at ruxolitinib start. With the exception of a transient increase after 3 months of ruxolitinib therapy, a progressive reduction in CD34(+) cells count was documented, down to a minimum of 0.063 x 10(9)/L after 36 months. We then assessed the association between spleen diameter expressed as the distance from the left costal margin (outcome) and log(CD34(+)) cells count using random-intercept and random slope multivariable regression models to take into account within subject correlation: after adjusting for time and ruxolitinib dosage, we estimated a 0.7 cm increase (95% confidence interval 0.2-1.2, p = 0.003) in spleen length for each unit increase in log(CD34(+)) cells count (x 10(9)/L). Although our study has some limitations, mainly related to its retrospective design, our approach may introduce a reproducible and simple tool that could facilitate the assessment of spleen response more objectively in patients with MF treated with ruxolitinib.
CD34+; myelofibrosis; response; ruxolitinib; splenomegaly
Settore MED/15 - Malattie del Sangue
feb-2023
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/962176
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