Gut microbiota has been shown to systemically shape the immunological landscape, modulate homeostasis and play a role in both health and disease. Dysbiosis of gut microbiota promotes inflammation and contributes to the pathogenesis of several major disorders in gastrointestinal tract, metabolic, neurological and respiratory diseases. Much effort is now focused on understanding host-microbes interactions and new microbiota-targeted therapies are deeply investigated as a means to restore health or prevent disease.This review details the immunoregulatory role of the gut microbiota in health and disease and discusses the most recent strategies in manipulating individual patient's microbiota for the management and prevention of inflammatory conditions.

Microbiota-targeted therapies in inflammation resolution / F. Strati, G. Lattanzi, C. Amoroso, F. Facciotti. - In: SEMINARS IN IMMUNOLOGY. - ISSN 1044-5323. - 59:(2022 Jan), pp. 101599.1-101599.14. [10.1016/j.smim.2022.101599]

Microbiota-targeted therapies in inflammation resolution

G. Lattanzi
Secondo
;
2022

Abstract

Gut microbiota has been shown to systemically shape the immunological landscape, modulate homeostasis and play a role in both health and disease. Dysbiosis of gut microbiota promotes inflammation and contributes to the pathogenesis of several major disorders in gastrointestinal tract, metabolic, neurological and respiratory diseases. Much effort is now focused on understanding host-microbes interactions and new microbiota-targeted therapies are deeply investigated as a means to restore health or prevent disease.This review details the immunoregulatory role of the gut microbiota in health and disease and discusses the most recent strategies in manipulating individual patient's microbiota for the management and prevention of inflammatory conditions.
FMT; Gut microbiome; Inflammation; Live biotherapeutic products; Mucosal immunity; Probiotics;
Settore MED/07 - Microbiologia e Microbiologia Clinica
gen-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/958236
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