Advanced glycation end products (AGEs) are aging products. In chronic kidney disease (CKD), AGEs accumulate due to the increased production, reduced excretion, and the imbalance between oxidant/antioxidant capacities. CKD is therefore a model of aging. The aim of this review is to summarize the present knowledge of AGEs in CKD onset and progression, also focusing on CKD-related disorders (cardiovascular diseases, sarcopenia, and nutritional imbalance) and CKD mortality. The role of AGEs as etiopathogenetic molecules, as well as potential markers of disease progression and/or therapeutic targets, will be discussed.

Accelerated AGEing: The Impact of Advanced Glycation end Products on the Prognosis of Chronic Kidney Disease / E. Dozio, L. Caldiroli, P. Molinari, G. Castellano, N.W. Delfrate, M.M. CORSI ROMANELLI, A. Simone Vettoretti. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 12:3(2023 Feb 26), pp. 584.1-584.23. [10.3390/antiox12030584]

Accelerated AGEing: The Impact of Advanced Glycation end Products on the Prognosis of Chronic Kidney Disease

E. Dozio
Primo
;
P. Molinari;G. Castellano;N.W. Delfrate;M.M. CORSI ROMANELLI;
2023

Abstract

Advanced glycation end products (AGEs) are aging products. In chronic kidney disease (CKD), AGEs accumulate due to the increased production, reduced excretion, and the imbalance between oxidant/antioxidant capacities. CKD is therefore a model of aging. The aim of this review is to summarize the present knowledge of AGEs in CKD onset and progression, also focusing on CKD-related disorders (cardiovascular diseases, sarcopenia, and nutritional imbalance) and CKD mortality. The role of AGEs as etiopathogenetic molecules, as well as potential markers of disease progression and/or therapeutic targets, will be discussed.
advanced glycation end products (AGEs); aging; cardiovascular diseases; chronic kidney disease (CKD); inflammation; mortality; pro-oxidant milieu; sarcopenia
Settore MED/05 - Patologia Clinica
Settore MED/14 - Nefrologia
26-feb-2023
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/956503
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