Association of coronary artery Doppler-echocardiography diastolic-systolic velocity ratio at rest with obstructive coronary artery stenosis on the left main or left anterior descending coronary artery

Background: We assessed whether the non-invasive measure of peak diastolic-systolic velocity ratio (rDSVR) at rest on the left anterior descending artery (LAD) using Doppler transthoracic echocardiography is associated with obstructive coronary artery disease (CAD) on the LAD and left main (LM) arteries. We compared rDSVR diagnostic accuracy with stress wall motion (WM) and coronary flow reserve (CFR-LAD), in a group of subjects who underwent contrast stress-echocardiography (cSE) and coronary angiography within 3 months. Methods: 286 patients selected with a clinical indication to cSE, in which CFR-LAD was measured during the test who also underwent coronary angiography within 3 months were selected and diagnostic performance compared. Results: Demographics and clinical variables were univariate predictors of LAD or LMN50% stenosis, but rDSVR < 1.7 outperformed other variables (OR 11.18, 95% CI 5.82-21.49, p < 0.001), comprising cSE variables such as reversible WMabnormalities (OR 1.53, 95% CI 0.94-2.49, p=0.087) or CFR-LAD < 2 (OR 2.88, 95% CI 21.74-4.77, p < 0.001). The addition of rDSVR to multivariate logistic regression models (clinical or clinical+cSE variables) led to a marked increase in C-index (0.82, 95% CI 0.78-0.87) with significant improvement compared to all prior models (p < 0.001). Conclusions: Our data suggest a strict association of reduced rDSVR with N50% coronary artery stenosis on the LM/LAD, superior to other standard clinical or cSE related indexes, such as WM assessment or CFR-LAD, and builds incrementally to them and clinical variables inmultivariable logistic models for the prediction of CAD on LMand LAD coronaries. (c) 2019 Elsevier B. V. All rights reserved.