We examined the impact of a lamivudine-containing highly active antiretroviral therapy (HAART) regimen on 164 hepatitis B virus/HIV co-infected individuals starting their first HAART. Lamivudine-treated patients (accounting for 73% of the study population) showed a significantly lower level of alanine aminotransferase over follow-up [-81.1 mU/ml mean difference; 95% confidence intervals (95% CI): -30.3; -131.7, P=0.003] and a significantly reduced risk of liver-related morbidity/mortality [Relative hazard (RH)=0.07; 95% CI: 0.01-0.38, P=0.002] than those starting a lamivudine sparing-regimen.
|Titolo:||The management of hepatitis B virus (HBV) / HIV-1 co-infected patients starting their first HAART regimen : treating two infections at the price of one drug ?|
|Autori interni:||D'ARMINIO MONFORTE, ANTONELLA (Ultimo)|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||2004|
|Appare nelle tipologie:||01 - Articolo su periodico|