The use of cellulose nanocrystals (CNCs) as a biomaterial able to inhibit host cell bacterial adhesion is described. Pre-incubation of E. coli ATCC 25922 with a suspension of 0.1% CNCs afforded a significant 2log reduction of bacterial adhesion to the intestinal cell monolayer HT29. This effect could be attributed to the interaction between the CNCs and the bacterial cell surface as confirmed using fluorescence microscopy experiments.
Cellulose nanocrystals are effective in inhibiting host cell bacterial adhesion / G. D'Orazio, L. Munizza, J. Zampolli, M. Forcella, L. Zoia, P. Fusi, P. Di Gennaro, B. La Ferla. - In: JOURNAL OF MATERIALS CHEMISTRY. B. - ISSN 2050-7518. - 5:34(2017 Sep 14), pp. 7018-7020. [10.1039/c7tb01923h]
Cellulose nanocrystals are effective in inhibiting host cell bacterial adhesion
G. D'Orazio;
2017
Abstract
The use of cellulose nanocrystals (CNCs) as a biomaterial able to inhibit host cell bacterial adhesion is described. Pre-incubation of E. coli ATCC 25922 with a suspension of 0.1% CNCs afforded a significant 2log reduction of bacterial adhesion to the intestinal cell monolayer HT29. This effect could be attributed to the interaction between the CNCs and the bacterial cell surface as confirmed using fluorescence microscopy experiments.
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