We performed an in-depth analysis of the virucidal effect of discrete wavelengths: UV-C (278 nm), UV-B (308 nm), UV-A (366 nm) and violet (405 nm) on SARS-CoV-2. By using a highly infectious titer of SARS-CoV-2 we observed that the violet light-dose resulting in a 2-log viral inactivation is only 10−4 times less efficient than UV-C light. Moreover, by qPCR and fluorescence in situ hybridization (FISH) approach we verified that the viral titer typically found in the sputum of COVID-19 patients can be completely inactivated by the long UV-wavelengths corresponding to UV-A and UV-B solar irradiation. The comparison of the UV action spectrum on SARS-CoV-2 to previous results obtained on other pathogens suggests that RNA viruses might be particularly sensitive to long UV wavelengths. Our data extend previous results showing that SARS-CoV-2 is highly susceptible to UV light and offer an explanation to the reduced incidence of SARS-CoV-2 infection seen in the summer season.

{UV}-A and {UV}-B Can Neutralize {SARS}-{CoV}-2 Infectivity / M. Biasin, S. Strizzi, A. Bianco, A. Macchi, O.M. Utyro, G. Pareschi, A. Loffreda, A. Cavalleri, M. Lualdi, D.L. Trabattoni, C. Tacchetti, D. Mazza, M.S. Clerici. - (2021 May 31). [10.1101/2021.05.28.21257989]

{UV}-A and {UV}-B Can Neutralize {SARS}-{CoV}-2 Infectivity

M. Biasin;S. Strizzi;A. Bianco;A. Macchi;O.M. Utyro;M. Lualdi;D.L. Trabattoni;M.S. Clerici
2021

Abstract

We performed an in-depth analysis of the virucidal effect of discrete wavelengths: UV-C (278 nm), UV-B (308 nm), UV-A (366 nm) and violet (405 nm) on SARS-CoV-2. By using a highly infectious titer of SARS-CoV-2 we observed that the violet light-dose resulting in a 2-log viral inactivation is only 10−4 times less efficient than UV-C light. Moreover, by qPCR and fluorescence in situ hybridization (FISH) approach we verified that the viral titer typically found in the sputum of COVID-19 patients can be completely inactivated by the long UV-wavelengths corresponding to UV-A and UV-B solar irradiation. The comparison of the UV action spectrum on SARS-CoV-2 to previous results obtained on other pathogens suggests that RNA viruses might be particularly sensitive to long UV wavelengths. Our data extend previous results showing that SARS-CoV-2 is highly susceptible to UV light and offer an explanation to the reduced incidence of SARS-CoV-2 infection seen in the summer season.
Settore MED/04 - Patologia Generale
Settore BIO/13 - Biologia Applicata
31-mag-2021
https://www.medrxiv.org/content/10.1101/2021.05.28.21257989v1.article-info
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/954515
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