Current therapies for malignant peripheral nerve sheath tumors (MPNSTs) are ineffective. The study by Wu et al. in this issue of Cancer Cell provides evidence that the HIPPO pathway is overactive in human MPNSTs and that combined modulation of LATS1/2-YAP/TAZ and PDGFR signaling in Schwann cells reduces MPNST growth.
HIPPO Stampede in Nerve Sheath Tumors / M. Feltri, Y. Poitelon. - In: CANCER CELL. - ISSN 1535-6108. - 33:2(2018), pp. 160-161. [10.1016/j.ccell.2018.01.016]
HIPPO Stampede in Nerve Sheath Tumors
M. Feltri
Primo
;
2018
Abstract
Current therapies for malignant peripheral nerve sheath tumors (MPNSTs) are ineffective. The study by Wu et al. in this issue of Cancer Cell provides evidence that the HIPPO pathway is overactive in human MPNSTs and that combined modulation of LATS1/2-YAP/TAZ and PDGFR signaling in Schwann cells reduces MPNST growth.File in questo prodotto:
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