Total antioxidant capacity and total oxidant status and disease severity in a cohort study of COVID-19 patients

Previous reports have suggested the role of oxidative stress in progression of COVID-19 infection, but there is limited information regarding the effect of antioxidant capacity and total oxidant status of patients with COVID-19 on disease severity. In the present study, we aimed to investigate the relationship between total antioxidant capacity (TAC), total oxidant status (TOS), TAC/TOS levels, and disease severity in hospitalized pa- tients with COVID-19. Methods: This cohort study was carried out at Masih Daneshvari Hospital in Tehran, Iran, from September 2020 to October 2020. Clinical data of 331 patients with COVID-19 admitted to the hospital were analyzed and divided into mild, moderate, and severe groups (needed oxygen, intubation, and mechanical ventilation). The patients’ TAC, TOS, and TAC/TOS levels were assessed using the serum samples by colorimetric assay kit. Results: We found no significant difference in serum levels of TAC, TOS, and TAC/TOS in terms of the disease se- verity. Conclusions: These results indicated that total antioxidant capacity and total oxidant status may not be the deter- mining factor on the disease severity.