Objective: The present retrospective study investigated the effect of chronic intake of proton pump inhibitors, selective serotonin uptake inhibitors, anti-inflammatory, and antihypertensive drugs on the survival of dental implants and on the occurrence of peri-implantitis. Materials and methods: Survival analyses for implant failure and peri-implantitis were performed patient level for each drug subcategory and for risk factors. The HR for each drug was calculated with adjusted models as compared with a control group made of subjects not assuming the specific drug. Multilevel logistic regression was used to explore the influence of implant-level and patient-level variables on the outcomes. Results: A total of 270 subjects receiving 1118 dental implants were included, with a mean follow-up time of 5.19 ± 4.22 years. After 10 years, the survival rate was 86.9% (patient level), and according to survival analysis, 61.3% of subjects were free from peri-implantitis. The use of anti-inflammatory medicines produced a significant effect (p =.04) on peri-implantitis as compared to subjects not using the drug, with a 2.7-year drop in the mean survival time. The HR was slightly above the level of significance in a semiadjusted model (p =.058). The multilevel analysis found a significant effect on the entire sample and not when considering only subjects with implants with more than 1-year follow-up. Conclusions: We found a possible relationship between anti-inflammatory drug use and the occurrence of peri-implantitis in the examined cohort of patients, and no correlation for the other drugs.

The effect of the use of proton pump inhibitors, serotonin uptake inhibitors, antihypertensive, and anti-inflammatory drugs on clinical outcomes of functional dental implants : A retrospective study / S. Corbella, P. Morandi, A. Alberti, B. Morandi, L.A. Francetti. - In: CLINICAL ORAL IMPLANTS RESEARCH. - ISSN 0905-7161. - 33:8(2022 Aug), pp. 834-843. [10.1111/clr.13964]

The effect of the use of proton pump inhibitors, serotonin uptake inhibitors, antihypertensive, and anti-inflammatory drugs on clinical outcomes of functional dental implants : A retrospective study

S. Corbella
Primo
;
P. Morandi
Secondo
;
A. Alberti;B. Morandi
Penultimo
;
L.A. Francetti
Ultimo
2022

Abstract

Objective: The present retrospective study investigated the effect of chronic intake of proton pump inhibitors, selective serotonin uptake inhibitors, anti-inflammatory, and antihypertensive drugs on the survival of dental implants and on the occurrence of peri-implantitis. Materials and methods: Survival analyses for implant failure and peri-implantitis were performed patient level for each drug subcategory and for risk factors. The HR for each drug was calculated with adjusted models as compared with a control group made of subjects not assuming the specific drug. Multilevel logistic regression was used to explore the influence of implant-level and patient-level variables on the outcomes. Results: A total of 270 subjects receiving 1118 dental implants were included, with a mean follow-up time of 5.19 ± 4.22 years. After 10 years, the survival rate was 86.9% (patient level), and according to survival analysis, 61.3% of subjects were free from peri-implantitis. The use of anti-inflammatory medicines produced a significant effect (p =.04) on peri-implantitis as compared to subjects not using the drug, with a 2.7-year drop in the mean survival time. The HR was slightly above the level of significance in a semiadjusted model (p =.058). The multilevel analysis found a significant effect on the entire sample and not when considering only subjects with implants with more than 1-year follow-up. Conclusions: We found a possible relationship between anti-inflammatory drug use and the occurrence of peri-implantitis in the examined cohort of patients, and no correlation for the other drugs.
anti-inflammatory agents; antihypertensive agents; bone resorption; dental implants; peri-implantitis; proton pump inhibitors; serotonin uptake inhibitors; anti-inflammatory agents; antihypertensive agents; humans; proton pump inhibitors; proton pumps; retrospective studies; serotonin uptake inhibitors; dental implants; peri-implantitis
Settore MED/28 - Malattie Odontostomatologiche
ago-2022
Article (author)
File in questo prodotto:
File Dimensione Formato  
CLR13964.PDF

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 919.17 kB
Formato Adobe PDF
919.17 kB Adobe PDF Visualizza/Apri
Clinical Oral Implants Res - 2022 - Corbella - The effect of the use of proton pump inhibitors serotonin uptake inhibitors.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 933.2 kB
Formato Adobe PDF
933.2 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/953835
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 4
social impact