Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), previously termed drug-related baboon syndrome, is an uncommon drug eruption. It is characterized by symmetrical erythema involving the gluteal and/or inguinal area in association with one other intertriginous area in the absence of systemic involvement. It typically develops a few hours to days after drug exposure. The diagnosis is based on clinical presentation and drug history. The treatment consists mainly of withdrawal of the causative agent; corticosteroids (topical or systemic) are prescribed to accelerate the resolution. We present three cases that appeared after proton-pump inhibitors (PPIs) intake.

Three cases of symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) induced by proton-pump inhibitors / C.B. Spigariolo, F. Barei, C.A. Maronese, F. Barberi, A. Cattaneo, S.A. Violetti. - In: AUSTRALASIAN JOURNAL OF DERMATOLOGY. - ISSN 0004-8380. - 63:4(2022 Nov), pp. 509-512. [10.1111/ajd.13905]

Three cases of symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) induced by proton-pump inhibitors

C.B. Spigariolo
Primo
;
F. Barei
Secondo
;
C.A. Maronese;F. Barberi;S.A. Violetti
Ultimo
2022

Abstract

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), previously termed drug-related baboon syndrome, is an uncommon drug eruption. It is characterized by symmetrical erythema involving the gluteal and/or inguinal area in association with one other intertriginous area in the absence of systemic involvement. It typically develops a few hours to days after drug exposure. The diagnosis is based on clinical presentation and drug history. The treatment consists mainly of withdrawal of the causative agent; corticosteroids (topical or systemic) are prescribed to accelerate the resolution. We present three cases that appeared after proton-pump inhibitors (PPIs) intake.
cutaneous drug eruptions; proton-pump inhibitors (PPIs); symmetrical drug-related intertriginous and flexural exanthema (SDRIFE)
Settore MED/35 - Malattie Cutanee e Veneree
nov-2022
25-lug-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/953451
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