Oxidative stress (OS) can have an impact in the pathogenesis and in the progression of thyroid cancer. We investigated the levels of reactive oxygen species (ROS) in 50 malignant and benign thyroid lesions and 41 normal tissues, and correlated them with the thyroid differentiation score-TDS and the clinico-pathologic features. NOX4 expression, GPx activity and the genetic pattern of tumors were evaluated. In malignant and benign lesions, ROS generation and NOX4 protein expression were higher than in normal tissues. Follicular (FTCs) and anaplastic/poorly differentiated cancers had increased OS relative to papillary tumors (PTCs). Moreover, OS in FTCs was higher than in follicular adenomas. Mutated PTCs showed increased OS compared with non-mutated PTCs. In malignant tumors, OS was inversely correlated with TDS, and directly correlated with tumor stage and ATA risk. GPx activity was increased in tumors compared with normal tissues, and inversely correlated to OS. In conclusion, our data indicate that thyroid tumors are exposed to higher OS compared with normal tissues, while showing a compensative increased GPx activity. OS correlates with tumor aggressiveness and mutations in the MEK-ERK pathway in PTC. The inverse correlation between OS and TDS suggests that ROS may repress genes involved in thyroid differentiation.

Oxidative Stress Correlates with More Aggressive Features in Thyroid Cancer / M. Muzza, G. Pogliaghi, C. Colombo, E. Carbone, V. Cirello, S. Palazzo, F. Frattini, D. Gentilini, G. Gazzano, L. Persani, L. Fugazzola. - In: CANCERS. - ISSN 2072-6694. - 14:23(2022), pp. 5857.1-5857.13. [10.3390/cancers14235857]

Oxidative Stress Correlates with More Aggressive Features in Thyroid Cancer

M. Muzza
;
G. Pogliaghi
Secondo
;
C. Colombo;V. Cirello;D. Gentilini;L. Persani
Penultimo
;
L. Fugazzola
Ultimo
2022

Abstract

Oxidative stress (OS) can have an impact in the pathogenesis and in the progression of thyroid cancer. We investigated the levels of reactive oxygen species (ROS) in 50 malignant and benign thyroid lesions and 41 normal tissues, and correlated them with the thyroid differentiation score-TDS and the clinico-pathologic features. NOX4 expression, GPx activity and the genetic pattern of tumors were evaluated. In malignant and benign lesions, ROS generation and NOX4 protein expression were higher than in normal tissues. Follicular (FTCs) and anaplastic/poorly differentiated cancers had increased OS relative to papillary tumors (PTCs). Moreover, OS in FTCs was higher than in follicular adenomas. Mutated PTCs showed increased OS compared with non-mutated PTCs. In malignant tumors, OS was inversely correlated with TDS, and directly correlated with tumor stage and ATA risk. GPx activity was increased in tumors compared with normal tissues, and inversely correlated to OS. In conclusion, our data indicate that thyroid tumors are exposed to higher OS compared with normal tissues, while showing a compensative increased GPx activity. OS correlates with tumor aggressiveness and mutations in the MEK-ERK pathway in PTC. The inverse correlation between OS and TDS suggests that ROS may repress genes involved in thyroid differentiation.
BRAF; H; 2; O; 2; oxidative stress; thyroid adenoma; thyroid cancer
Settore MED/13 - Endocrinologia
Settore MED/06 - Oncologia Medica
   New insights into the molecular signature of differentiated thyroid cancer: implications for diagnosis, prognosis and therapy
   MINISTERO DELL'ISTRUZIONE E DEL MERITO
   2017YTWKWH_002
2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/953171
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