Lomitapide is a microsomal triglyceride transfer protein inhibitor for patients with homozygous familial hypercholesterolaemia. Due to its mechanism of action, potential hepatic effects of lomitapide are of clinical interest. This study aimed to determine the long-term hepatic safety of lomitapide.

Long-term hepatic safety of lomitapide in homozygous familial hypercholesterolaemia / L. Dominique, D. Laura, O. Sallyann, A. Marcello, I. Working Group on Lomitapide: Angelo Baldassare Cefalù, A. Di Costanzo, S. Bini, A. Giammanco, M. Averna, G. Iannuzzo, G. Fortunato, M. Gentile, M. Donata Di Taranto, A. Pujia, T. Montalcini, C. Pavanello, L. Calabresi, G. Battista Vigna, M. Bucci, K. Bonomo, T. Sampietro, F. Sbrana, P. Suppressa, C. Sabbà, F. Fimiani, A. Cesaro, P. Calabrò, F. Ventura, S. D'Addato, L. Pisciotta, S. Bertolini. - In: LIVER INTERNATIONAL. - ISSN 1478-3223. - 43:2(2023 Feb), pp. 413-423. [10.1111/liv.15497]

Long-term hepatic safety of lomitapide in homozygous familial hypercholesterolaemia

C. Pavanello;L. Calabresi;
2023

Abstract

Lomitapide is a microsomal triglyceride transfer protein inhibitor for patients with homozygous familial hypercholesterolaemia. Due to its mechanism of action, potential hepatic effects of lomitapide are of clinical interest. This study aimed to determine the long-term hepatic safety of lomitapide.
hepatic; hepatic biomarkers; hepatic steatosis; homozygous familial hypercholesterolaemia; liver; liver fibrosis; lomitapide
Settore MED/09 - Medicina Interna
Settore BIO/14 - Farmacologia
Settore BIO/18 - Genetica
feb-2023
15-dic-2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/952645
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