Porokeratosis encompass a group of acquired and familial, preneoplastic, keratinization disorders, clinically characterized by atrophic macules or patches with a peripheral keratotic rim, the cornoid lamella. Genetic background is recognized as crucial in its pathophysiology, while immunosuppression and ultraviolet radiation represent triggering factors. We report the case of a woman who developed disseminate superficial actinic porokeratosis following the intake of hydroxyurea for a polycythaemia vera. Clinical, dermoscopic and histopathology data are showed, and the role of drug as a second-hit mutation trigger is discussed.

Disseminated superficial actinic porokeratosis following hydroxyurea treatment: A case report / M. Romagnuolo, D. Riva, S. Alberti Violetti, A. Di Benedetto, F. Barberi, C. Moltrasio. - In: AUSTRALASIAN JOURNAL OF DERMATOLOGY. - ISSN 0004-8380. - 64:1(2023 Feb), pp. E72-E75. [10.1111/ajd.13943]

Disseminated superficial actinic porokeratosis following hydroxyurea treatment: A case report

M. Romagnuolo
Primo
;
D. Riva
Secondo
;
S. Alberti Violetti;A. Di Benedetto;F. Barberi
Penultimo
;
2023

Abstract

Porokeratosis encompass a group of acquired and familial, preneoplastic, keratinization disorders, clinically characterized by atrophic macules or patches with a peripheral keratotic rim, the cornoid lamella. Genetic background is recognized as crucial in its pathophysiology, while immunosuppression and ultraviolet radiation represent triggering factors. We report the case of a woman who developed disseminate superficial actinic porokeratosis following the intake of hydroxyurea for a polycythaemia vera. Clinical, dermoscopic and histopathology data are showed, and the role of drug as a second-hit mutation trigger is discussed.
Porokeratosis; adverse effect; genetic analysis; hydroxyurea; squamous cells neoplasm mevalonate kinase deficiency
Settore MED/35 - Malattie Cutanee e Veneree
feb-2023
1-nov-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/952002
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