Aim: To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). Patients & methods: 213 patients were included. Inclusion criteria: Nonmetastatic, MIBC (cT2-T4aN0M0), at least three cycles of NAC, undergone RC and with blood count within 30 days before NAC. Results: Five-years overall survival (OS) with NPAR >18 was 34.06% (95% CI: 18.3-50.5) and 65.37% (95% CI: 52.4-75.6) with NPAR <18. Five years cancer-specific survival (CSS) with NPAR >18 was 42.9% (95% CI: 23.9-60.7) and 74.5% (95% CI: 62.6-83.1) with NPAR <18 (p < 0.001). In multivariable analysis, NPAR increased OS of 1.3 points and CSS of 4.37 points. Conclusion: High NPAR prior to NAC seems to be a strong predictor of OS and CSS in MIBC patients treated with NAC and RC.Lay abstract: This research demonstrated that presence of a high neutrophil percentage-to-albumin ratio in patients with muscle-invasive bladder cancer prior neoadjuvant chemotherapy and radical cystectomy is associated with worse outcomes and reduced overall and cancer-specific survival. Thus, neutrophil percentage-to-albumin ratio could be a useful biological marker in clinical practice to help predict outcomes for patients with muscle-invasive bladder cancer.

Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy / M. Ferro, D. Babă, O. de Cobelli, G. Musi, G. Lucarelli, D. Terracciano, A. Porreca, G.M. Busetto, F. Del Giudice, F. Soria, P. Gontero, F. Cantiello, R. Damiano, P. Rocco, R.M. Scarpa, A.R. Abu Farhan, R. Autorino, A. Brescia, M. Marchioni, A. Mari, A. Minervini, N. Longo, F. Chiancone, S. Perdona', B. Barone, P.D. Placido, M. Catellani, D. Bottero, P. Ditonno, M. Battaglia, S. Zamboni, A. Antonelli, F. Greco, G.I. Russo, S. Smelzo, R. Hurle, N. Crisan, M. Manfredi, F. Porpiglia, F. Crocetto, C. Buonerba, A. Danilesco, M.D. Vartolomei. - In: FUTURE SCIENCE OA. - ISSN 2056-5623. - 7:7(2021 Aug), pp. 2021-0008.1-2021-0008.10. [10.2144/fsoa-2021-0008]

Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy

O. de Cobelli;G. Musi;M. Catellani;A. Antonelli;F. Greco;
2021

Abstract

Aim: To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). Patients & methods: 213 patients were included. Inclusion criteria: Nonmetastatic, MIBC (cT2-T4aN0M0), at least three cycles of NAC, undergone RC and with blood count within 30 days before NAC. Results: Five-years overall survival (OS) with NPAR >18 was 34.06% (95% CI: 18.3-50.5) and 65.37% (95% CI: 52.4-75.6) with NPAR <18. Five years cancer-specific survival (CSS) with NPAR >18 was 42.9% (95% CI: 23.9-60.7) and 74.5% (95% CI: 62.6-83.1) with NPAR <18 (p < 0.001). In multivariable analysis, NPAR increased OS of 1.3 points and CSS of 4.37 points. Conclusion: High NPAR prior to NAC seems to be a strong predictor of OS and CSS in MIBC patients treated with NAC and RC.Lay abstract: This research demonstrated that presence of a high neutrophil percentage-to-albumin ratio in patients with muscle-invasive bladder cancer prior neoadjuvant chemotherapy and radical cystectomy is associated with worse outcomes and reduced overall and cancer-specific survival. Thus, neutrophil percentage-to-albumin ratio could be a useful biological marker in clinical practice to help predict outcomes for patients with muscle-invasive bladder cancer.
bladder cancer; neoadjuvant chemotherapy; neutrophil percentage-to-albumin ratio; neutrophil-to-lymphocyte ratio; survival
Settore MED/24 - Urologia
ago-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/952000
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