Since the approval of three hydroxamic acid-based HDAC inhibitors as anticancer drugs, such functional groups acquired even more notoriety in synthetic medicinal chemistry. The ability of hydroxamic acids (HAs) to chelate metal ions makes this moiety an attractive metal binding group - in particular, Fe(III) and Zn(II) - so that HA derivatives find wide applications as metalloenzymes inhibitors. In this minireview, we will discuss the most relevant features concerning hydroxamic acid derivatives. In a first instance, the physicochemical characteristics of HAs will be summarized; then, an exhaustive description of the most relevant methods for the introduction of such moiety into organic substrates and an overview of their uses in medicinal chemistry will be presented.

Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications / A. Citarella, D. Moi, L. Pinzi, D. Bonanni, G. Rastelli. - In: ACS OMEGA. - ISSN 2470-1343. - 6:34(2021 Aug 20), pp. 21843-21849. [10.1021/acsomega.1c03628]

Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications

A. Citarella
Primo
;
2021

Abstract

Since the approval of three hydroxamic acid-based HDAC inhibitors as anticancer drugs, such functional groups acquired even more notoriety in synthetic medicinal chemistry. The ability of hydroxamic acids (HAs) to chelate metal ions makes this moiety an attractive metal binding group - in particular, Fe(III) and Zn(II) - so that HA derivatives find wide applications as metalloenzymes inhibitors. In this minireview, we will discuss the most relevant features concerning hydroxamic acid derivatives. In a first instance, the physicochemical characteristics of HAs will be summarized; then, an exhaustive description of the most relevant methods for the introduction of such moiety into organic substrates and an overview of their uses in medicinal chemistry will be presented.
Settore CHIM/06 - Chimica Organica
20-ago-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/951688
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