Magnesium (Mg) is involved in the regulation of metabolism and in the maintenance of the homeostasis of all the tissues, including the brain, where it harmonizes nerve signal transmission and preserves the integrity of the blood–brain barrier. Mg deficiency contributes to systemic low-grade inflammation, the common denominator of most diseases. In particular, neuroinflammation is the hallmark of neurodegenerative disorders. Starting from a rapid overview on the role of magnesium in the brain, this narrative review provides evidences linking the derangement of magnesium balance with multiple sclerosis, Alzheimer’s, and Parkinson’s diseases.

Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration / J.A.M. Maier, L. Locatelli, G. Fedele, A. Cazzaniga, A. Mazur. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 24:1(2022 Dec 23), pp. 223.1-223.14. [10.3390/ijms24010223]

Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration

G. Fedele
Membro del Collaboration Group
;
A. Cazzaniga
Penultimo
Membro del Collaboration Group
;
2022

Abstract

Magnesium (Mg) is involved in the regulation of metabolism and in the maintenance of the homeostasis of all the tissues, including the brain, where it harmonizes nerve signal transmission and preserves the integrity of the blood–brain barrier. Mg deficiency contributes to systemic low-grade inflammation, the common denominator of most diseases. In particular, neuroinflammation is the hallmark of neurodegenerative disorders. Starting from a rapid overview on the role of magnesium in the brain, this narrative review provides evidences linking the derangement of magnesium balance with multiple sclerosis, Alzheimer’s, and Parkinson’s diseases.
blood–brain barrier; brain; magnesium; neurodegeneration; neuroinflammation
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/951571
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