An enantioselective phosphine-catalyzed [3+2] cycloaddition between aza-aurones and allenoates is here described. The reaction proceeded under mild reaction conditions to afford 2-spirocyclopentyl indolin-3-one derivatives as single gamma-isomer and with high levels of stereocontrol.
Phosphine‐Catalyzed [3+2] Cycloaddition of Aza‐Aurones and Allenoates: Enantioselective Synthesis of 2‐Spirocyclopentyl‐Indolin‐3‐Ones / E. Brambilla, C. Pozza, S. Rizzato, G. Abbiati, V. Pirovano. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - (2022 Dec), pp. e202201385.1-e202201385.5. [Epub ahead of print] [10.1002/ejoc.202201385]
Phosphine‐Catalyzed [3+2] Cycloaddition of Aza‐Aurones and Allenoates: Enantioselective Synthesis of 2‐Spirocyclopentyl‐Indolin‐3‐Ones
E. BrambillaPrimo
Membro del Collaboration Group
;C. PozzaMembro del Collaboration Group
;S. RizzatoMembro del Collaboration Group
;G. AbbiatiPenultimo
Membro del Collaboration Group
;V. Pirovano
Ultimo
Membro del Collaboration Group
2022
Abstract
An enantioselective phosphine-catalyzed [3+2] cycloaddition between aza-aurones and allenoates is here described. The reaction proceeded under mild reaction conditions to afford 2-spirocyclopentyl indolin-3-one derivatives as single gamma-isomer and with high levels of stereocontrol.
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