For women affected by breast cancer who carry germline BRCA1/2 pathogenic variants, the classic standard treatment consists of therapeutic unilateral mastectomy and risk-reducing contralateral mastectomy. However, data from recent literature demonstrate that for women treated with breast-conserving surgery who receive adequate adjuvant treatments, the increased risk of locoregional recurrences and a breast cancer-related prognosis is not significant. This review describes the clinical factors that could help clinicians decide either against or in favor of a more aggressive type of breast cancer surgery.

Points to Consider Regarding De-Escalation Surgery in High-Risk Breast Cancer / G. Corso, F. Magnoni, P. Veronesi. - In: ANNALS OF SURGICAL ONCOLOGY. - ISSN 1068-9265. - 29:13(2022 Dec), pp. 8084-8089. [10.1245/s10434-022-12542-9]

Points to Consider Regarding De-Escalation Surgery in High-Risk Breast Cancer

G. Corso
Primo
;
P. Veronesi
Ultimo
2022

Abstract

For women affected by breast cancer who carry germline BRCA1/2 pathogenic variants, the classic standard treatment consists of therapeutic unilateral mastectomy and risk-reducing contralateral mastectomy. However, data from recent literature demonstrate that for women treated with breast-conserving surgery who receive adequate adjuvant treatments, the increased risk of locoregional recurrences and a breast cancer-related prognosis is not significant. This review describes the clinical factors that could help clinicians decide either against or in favor of a more aggressive type of breast cancer surgery.
Settore MED/18 - Chirurgia Generale
dic-2022
15-set-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/950521
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