Germline BRCA2 pathogenic variant carriers are associated with prostate cancer risk. Ashkenazi Jewish people are at higher risk of breast cancer due to the high prevalence of specific founder germline BRCA1/2 variants. The distribution of these variants (BRCA1 vs. BRCA2) in Ashkenazi men with prostate cancer is not clear.

Prevalence of Germline BRCA1/2 Variants in Ashkenazi and Non-Ashkenazi Prostate Cancer Populations: A Systematic Review and Meta-Analysis / A. Cioffi, O. De Cobelli, P. Veronesi, C. La Vecchia, P. Maisonneuve, G. Corso. - In: CANCERS. - ISSN 2072-6694. - 15:1(2023 Jan 02), pp. 306.1-306.11. [10.3390/cancers15010306]

Prevalence of Germline BRCA1/2 Variants in Ashkenazi and Non-Ashkenazi Prostate Cancer Populations: A Systematic Review and Meta-Analysis

O. De Cobelli
Secondo
;
P. Veronesi;C. La Vecchia;G. Corso
Ultimo
2023

Abstract

Germline BRCA2 pathogenic variant carriers are associated with prostate cancer risk. Ashkenazi Jewish people are at higher risk of breast cancer due to the high prevalence of specific founder germline BRCA1/2 variants. The distribution of these variants (BRCA1 vs. BRCA2) in Ashkenazi men with prostate cancer is not clear.
prostate cancer; BRCA1 mutations; BRCA2 mutations; Ashkenazi; meta-analysis
Settore MED/01 - Statistica Medica
Settore MED/06 - Oncologia Medica
Settore MED/24 - Urologia
Settore MED/15 - Malattie del Sangue
Settore MED/18 - Chirurgia Generale
2-gen-2023
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/950347
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