We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells. In addition to increased methylation of chromatin proteins that favors senescence-associated secretory phenotype (SASP) activation, our study unraveled global hypo-methylation of RNA-binding proteins, which–we speculate–may promote their phase separation and stress granules formation.
Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress / R. Giambruno, T. Bonaldi. - In: MOLECULAR & CELLULAR ONCOLOGY. - ISSN 2372-3556. - 7:4(2020), pp. 1743808.1-1743808.3. [10.1080/23723556.2020.1743808]
Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress
T. Bonaldi
Ultimo
Writing – Review & Editing
2020
Abstract
We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells. In addition to increased methylation of chromatin proteins that favors senescence-associated secretory phenotype (SASP) activation, our study unraveled global hypo-methylation of RNA-binding proteins, which–we speculate–may promote their phase separation and stress granules formation.File | Dimensione | Formato | |
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