Starting from commercially available pyrrole- and thiophene-2-carboxylic acids 1 or thiophene- and furan-3-carboxylic acids 6, we report the synthesis of tricyclic fused quinolone and naphthyridone derivatives, in only three steps, by an intramolecular Heck cyclization. We also report the use of microwave irradiation to obtain, in some cases, better yields of cyclized products.
Synthesis of Tricyclic Quinolones and Naphthyridones by Intramolecular Heck Cyclization of Functionalized Electron-Rich Heterocycles / E.M. Beccalli, G. Broggini, M. Martinelli, G. Paladino, C. Zoni. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2005:10(2005 Jan), pp. 2091-2096. [10.1002/ejoc.200400817]
Synthesis of Tricyclic Quinolones and Naphthyridones by Intramolecular Heck Cyclization of Functionalized Electron-Rich Heterocycles
E.M. BeccalliPrimo
;M. Martinelli;G. PaladinoPenultimo
;C. ZoniUltimo
2005
Abstract
Starting from commercially available pyrrole- and thiophene-2-carboxylic acids 1 or thiophene- and furan-3-carboxylic acids 6, we report the synthesis of tricyclic fused quinolone and naphthyridone derivatives, in only three steps, by an intramolecular Heck cyclization. We also report the use of microwave irradiation to obtain, in some cases, better yields of cyclized products.
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