Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.

The overlapping burden of the three leading causes of disability and death in sub-Saharan African children / R.C. Reiner, C.A. Welgan, C.E. Troeger, M.M. Baumann, D.J. Weiss, A. Deshpande, B.F. Blacker, M.K. Miller-Petrie, L. Earl, S. Bhatt, H. Abolhassani, A.E. Abosetugn, E. Abu-Gharbieh, V. Adekanmbi, O.O. Adetokunboh, M. Aghaali, B. Aji, F. Alahdab, Z. Al-Aly, R.K. Alhassan, S. Ali, H. Alizade, S.M. Aljunid, A. Almasi-Hashiani, H.M. Al-Mekhlafi, K.A. Altirkawi, N. Alvis-Guzman, A.T. Amare, S. Amini, D.A. Amugsi, R. Ancuceanu, C.L. Andrei, F. Ansari, D. Anvari, S.C.Y. Appiah, J. Arabloo, O. Aremu, M.M.W. Atout, M. Ausloos, F. Ausloos, M.A. Ayanore, Y.A. Aynalem, Z.N. Azene, A. Badawi, A.A. Baig, M. Banach, N. Bedi, A.S. Bhagavathula, D. Bhandari, N. Bhardwaj, P. Bhardwaj, K. Bhattacharyya, Z.A. Bhutta, A. Bijani, T.T.M. Birhanu, Z.W. Bitew, A. Boloor, O.J. Brady, Z.A. Butt, J. Car, F. Carvalho, D.C. Casey, V.K. Chattu, M.A.K. Chowdhury, D.-. Chu, C.H. Coelho, A.J. Cook, G. Damiani, F. Daoud, J.D. Gela, A.H. Darwish, A. Daryani, J.K. Das, N. Davis Weaver, K. Deribe, A. Desalew, S.D. Dharmaratne, M. Dianatinasab, D. Diaz, S. Djalalinia, F. Dorostkar, E. Dubljanin, B. Duko, L. Dwyer-Lindgren, A. Effiong, M. El Sayed Zaki, M. El Tantawi, S. Enany, N. Fattahi, V.L. Feigin, E. Fernandes, P. Ferrara, F. Fischer, N.A. Foigt, M.O. Folayan, M. Foroutan, J.J. Frostad, T. Fukumoto, A.M. Gaidhane, H.G.G.K. Gebrekrstos, L. Gebremeskel, A.A. Gebreslassie, P.W. Gething, K.E. Gezae, K. Ghadiri, A. Ghashghaee, M. Golechha, M.I.M. Gubari, F.B. Hadgu, S. Hamidi, D.W. Handiso, A. Hashi, S. Hassan, K. Hayat, C. Herteliu, H.C. Ho, R. Holla, M. Hosseinzadeh, M. Househ, R. Hussain, B.-. Hwang, S.E. Ibitoye, O.S. Ilesanmi, I.M. Ilic, M.D. Ilic, S.S.N. Irvani, J. Jaafari, T. Javaheri, R.P. Jha, K.B. Johnson, J.B. Jonas, J.J. Jozwiak, A. Kabir, R. Kalhor, T. Kanchan, A. Karch, G.A. Kayode, P.N. Keiyoro, Y.S. Khader, I.A. Khalil, M.N. Khan, M. Khan, G. Khan, K. Khatab, M.M. Khater, M.N. Khatib, N. Kianipour, Y.J. Kim, R.W. Kimokoti, S. Kisa, A. Kisa, N. Kissoon, S. Kochhar, A. Koolivand, J.A. Kopec, A. Koyanagi, K. Krishan, P. Kumar, O.P. Kurmi, D. Kusuma, D.K. Lal, F.H. Lami, I. Landires, V.C. Lansingh, S. Lasrado, C. La Vecchia, A. Lazzar-Atwood, P.H. Lee, K.E. Legrand, S. Lewycka, B. Li, S.S. Lim, P.A. Lindstedt, X. Liu, J. Longbottom, A.D. Lopez, H. Magdy Abd El Razek, P.W. Mahasha, A. Maleki, A.A. Mamun, M.A. Mansournia, L.B. Marczak, F.R. Martins-Melo, B.K. Mayala, B.G. Meharie, A. Melese, W. Mendoza, R.G. Menezes, E.W. Mengesha, G.A. Mensah, T.J. Meretoja, T. Mestrovic, T.R. Miller, E.M. Mirrakhimov, B. Moazen, N. Mohammad Gholi Mezerji, S. Mohammadi, S. Mohammed, A.H. Mokdad, M. Moradi, R. Moradzadeh, P. Moraga, J.F. Mosser, C.J.L. Murray, M. Naderi, A.J. Nagarajan, J. Nazari, R. Ndejjo, I. Negoi, J.W. Ngunjiri, Q.A.P. Nguyen, H.L.T. Nguyen, C.A. Nnaji, J.J. Noubiap, V. Nunez-Samudio, A.T. Olagunju, J.O. Olusanya, B.O. Olusanya, M.O. Omer, O.E. Onwujekwe, N. Otstavnov, S.S. Otstavnov, M.O. Owolabi, M. P A, J.R. Padubidri, A. Pana, E.K. Peprah, H.Q. Pham, D.M. Pigott, M. Pirestani, M.J. Postma, F.H. Pottoo, H. Pourjafar, Z. Quazi Syed, F. Rahim, V. Rahimi-Movaghar, M.H.U. Rahman, S.J. Rao, P.C. Rao, P. Rathi, S. Rawaf, D.L. Rawaf, L. Rawal, R. Rawassizadeh, L.D. Regassa, A.M.N. Renzaho, N. Rezaei, M.S. Rezai, A.I. Ribeiro, J. Rickard, C.M. Rios-Gonzalez, S.F. Rumisha, S. Sabour, S.M. Sajadi, J.A. Salomon, H. Samadi Kafil, A.M. Samy, J. Sanabria, B. Sartorius, D. Saxena, L.E. Schaeffer, S. Senthilkumaran, F. Sha, A.A. Shaheen, M.A. Shaikh, R. Sharma, A. Sheikh, K. Shibuya, M. Shigematsu, J. Il Shin, B. Simonetti, J.A. Singh, D.L. Smith, A. Soheili, A. Sokhan, E.E. Spurlock, C.T. Sreeramareddy, M.B. Sufiyan, S.J. Swartz, D.B. Tadesse, A.T. Tamiru, Y.G. Tefera, M.-. Temsah, Z.T. Tessema, M.V. Titova, B.X. Tran, P.N. Truong, B. Unnikrishnan, E. Upadhyay, T.J. Vasankari, Y. Vasseghian, F.S. Violante, G.T. Vu, Y. Waheed, R.G. Wamai, E.G. Wassie, F.T. Welay, N.D. Wickramasinghe, K.E. Wiens, T. Wijeratne, C.S. Wiysonge, T.G. Wondmeneh, T. Yamada, S. Yaya, Y.G. Yeshitila, P. Yip, N. Yonemoto, C. Yu, D. Yuce, H. Yusefzadeh, Z. Zaidi, M. Zamanian, A. Zangeneh, Z.-. Zhang, Y. Zhang, A. Ziapour, S.I. Hay. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 13:1(2022 Dec 06), pp. 7457.1-7457.8. [10.1038/s41467-022-34240-6]

The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

G. Damiani
Membro del Collaboration Group
;
S. Hassan
Membro del Collaboration Group
;
C. La Vecchia
Membro del Collaboration Group
;
2022

Abstract

Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.
Children mortality; Sub-Saharian Africa
Settore MED/01 - Statistica Medica
Settore MED/42 - Igiene Generale e Applicata
Article (author)
File in questo prodotto:
File Dimensione Formato  
The overlapping Sub Saharan children GBD.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 4.15 MB
Formato Adobe PDF
4.15 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/947968
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact