This chapter provides an overview of the major epigenetic mechanisms, such as DNA methylation, histone modifi cations, and miRNA, and describes those epigenetic mechanisms that are altered in non- CDH1 associated familial gastric cancer. Moreover, we also discuss the clinical implications of the epigenome characterization for this familial gastric cancer setting, regarding its potential in therapy.
Non-CDH1-Associated Familial Gastric Cancer and Epigenetics Factors / M. Leite, G. Corso, S. Sousa, J. Carvalho, F. Roviello, C. Oliveira, R. Seruca - In: Spotlight on Familial and Hereditary Gastric Cancer / [a cura di] G. Corso, F. Roviello. - [s.l] : Springer, 2013. - ISBN 978-94-007-6569-6. - pp. 111-125 [10.1007/978-94-007-6570-2_10]
Non-CDH1-Associated Familial Gastric Cancer and Epigenetics Factors
G. CorsoSecondo
;
2013
Abstract
This chapter provides an overview of the major epigenetic mechanisms, such as DNA methylation, histone modifi cations, and miRNA, and describes those epigenetic mechanisms that are altered in non- CDH1 associated familial gastric cancer. Moreover, we also discuss the clinical implications of the epigenome characterization for this familial gastric cancer setting, regarding its potential in therapy.
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