Exposure to environmental pollutants is a serious and common public health concern as- sociated with growing morbidity and mortality worldwide, as well as economic burden. In recent years, the toxic effects associated with air pollution have been intensively studied, with a particular focus on the lung and cardiovascular system, mainly associated with particulate matter exposure. However, epidemiological and mechanistic studies suggest that air pollution can also influence skin integrity and may have a significant adverse impact on the immune and nervous system. Air pollu- tion exposure already starts in utero before birth, potentially causing delayed chronic diseases aris- ing later in life. There are, indeed, time windows during the life of individuals who are more sus- ceptible to air pollution exposure, which may result in more severe outcomes. In this review paper, we provide an overview of findings that have established the effects of air pollutants on the immune and nervous system, and speculate on the possible interaction between them, based on mechanistic data.

Air Pollution: Possible Interaction between the Immune and Nervous System? / M.M. Serafini, A. Maddalon, M. Iulini, V. Galbiati. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 19:23(2022), pp. 16037.1-16037.26. [10.3390/ijerph192316037]

Air Pollution: Possible Interaction between the Immune and Nervous System?

M.M. Serafini
Primo
;
A. Maddalon
Secondo
;
M. Iulini
Penultimo
;
V. Galbiati
Ultimo
2022

Abstract

Exposure to environmental pollutants is a serious and common public health concern as- sociated with growing morbidity and mortality worldwide, as well as economic burden. In recent years, the toxic effects associated with air pollution have been intensively studied, with a particular focus on the lung and cardiovascular system, mainly associated with particulate matter exposure. However, epidemiological and mechanistic studies suggest that air pollution can also influence skin integrity and may have a significant adverse impact on the immune and nervous system. Air pollu- tion exposure already starts in utero before birth, potentially causing delayed chronic diseases aris- ing later in life. There are, indeed, time windows during the life of individuals who are more sus- ceptible to air pollution exposure, which may result in more severe outcomes. In this review paper, we provide an overview of findings that have established the effects of air pollutants on the immune and nervous system, and speculate on the possible interaction between them, based on mechanistic data.
air pollution; immune system; skin; central nervous system; microbiota; hygiene hypothesis
Settore BIO/14 - Farmacologia
30-nov-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/947292
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