The cerebrospinal fluid (CSF)/serum albumin quotient (Q-Alb) is a marker of the blood-CSF barrier (BCSFB) and possibly of the blood-brain barrier (BBB). The latter is known to be altered in Alzheimer's disease (AD) based on neuropathological and neuroimaging studies. Following investigations performed on clinically diagnosed cohorts, we aimed at comparing Q-Alb in cognitively impaired patients with neurochemical demonstration of AD pathophysiology and neurological disease controls (NDCs).

Cerebrospinal fluid/serum albumin quotient (Q-Alb) is not increased in Alzheimer's disease compared to neurological disease controls: a retrospective study on 276 patients / E. Giacopuzzi Grigoli, F. Solca, I. Milone, E.N. Aiello, A. Dubini, A. Ratti, E. Torresani, B. Poletti, N. Ticozzi, E. Ciusani, V. Silani, F. Verde. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - (2022), pp. 1-5. [Epub ahead of print] [10.1007/s10072-022-06530-w]

Cerebrospinal fluid/serum albumin quotient (Q-Alb) is not increased in Alzheimer's disease compared to neurological disease controls: a retrospective study on 276 patients

E. Giacopuzzi Grigoli
Primo
;
A. Ratti;B. Poletti;N. Ticozzi
;
V. Silani
Penultimo
;
F. Verde
Ultimo
2022

Abstract

The cerebrospinal fluid (CSF)/serum albumin quotient (Q-Alb) is a marker of the blood-CSF barrier (BCSFB) and possibly of the blood-brain barrier (BBB). The latter is known to be altered in Alzheimer's disease (AD) based on neuropathological and neuroimaging studies. Following investigations performed on clinically diagnosed cohorts, we aimed at comparing Q-Alb in cognitively impaired patients with neurochemical demonstration of AD pathophysiology and neurological disease controls (NDCs).
Albumin quotient (Q-Alb); Alzheimer’s disease (AD); Blood-brain barrier (BBB); Blood-cerebrospinal fluid barrier (BCSFB); Cerebrospinal fluid (CSF);
Settore MED/26 - Neurologia
Settore M-PSI/08 - Psicologia Clinica
2022
28-nov-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/947189
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