Evidence accumulated over the past decades shows that the number of identified antisense transcripts is continuously increasing, promoting them from transcriptional noise to real genes with specific functions. Indeed, recent studies have begun to unravel the complexity of the antisense RNA (asRNA) world, starting from the multidimensional mechanisms that they can exert in physiological and pathological conditions. In this review, we discuss the multiverse of the molecular functions of asRNAs, describing their action through transcription-dependent and RNA-dependent mechanisms. Then, we report the workflow and methodologies to study and functionally characterize single asRNA candidates.

Navigating the Multiverse of Antisense RNAs: The Transcription- and RNA-Dependent Dimension / G. Pagani, C. Pandini, P. Gandellini. - In: NON-CODING RNA. - ISSN 2311-553X. - 8:6(2022 Oct 26), pp. 74.1-74.16. [10.3390/ncrna8060074]

Navigating the Multiverse of Antisense RNAs: The Transcription- and RNA-Dependent Dimension

G. Pagani
Co-primo
;
C. Pandini
Co-primo
;
P. Gandellini
Ultimo
2022

Abstract

Evidence accumulated over the past decades shows that the number of identified antisense transcripts is continuously increasing, promoting them from transcriptional noise to real genes with specific functions. Indeed, recent studies have begun to unravel the complexity of the antisense RNA (asRNA) world, starting from the multidimensional mechanisms that they can exert in physiological and pathological conditions. In this review, we discuss the multiverse of the molecular functions of asRNAs, describing their action through transcription-dependent and RNA-dependent mechanisms. Then, we report the workflow and methodologies to study and functionally characterize single asRNA candidates.
RNA-dependent mechanism; antisense RNA (asRNA); functional study; long non-coding RNA (lncRNA); transcription-dependent mechanism
Settore MED/04 - Patologia Generale
ASS_NAZ21PGAND_01 - Dissecting the role of NFY "noncoding-ome" in human cancer (1° anno) - GANDELLINI, PAOLO - ASS_NAZ - Bandi da Associazioni e altri Finanziatori privati nazionali - 2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/946561
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