Ultra-small gold nanoparticles (UAuNPs) are extremely interesting for applications in nanomedicine thanks to their good stability, biocompatibility, long circulation time and efficient clearance pathways. UAuNPs engineered with glycans (Glyco- UAuNPs) emerged as excellent platforms for many applications since the multiple copies of glycans can mimic the multivalent effect of glycoside clusters. Herein, we unravel a straightforward photo-induced synthesis of Glyco-UAuNPs based on a reliable and robust microfluidic approach. The synthesis occurs at room temperature avoiding the use of any further chemical reductant, templating agents or co-solvents. Exploiting 1H-NMR spectroscopy, we showed that the amount of thiol-ligand exposed on the UAuNPs is linearly correlated to the ligand concentration in the initial mixture. The results pave the way towards the development of a programmable synthetic approach, enabling an accurate design of the engineered UAuNPs or smart hybrid nano- systems.

Photo-Induced Microfluidic Production of Ultrasmall Glyco Gold Nanoparticles / P. Perez Schmidt, K. Pagano, C. Lenardi, M. Penconi, R. MATEU FERRANDO, C. Evangelisti, L. Lay, L. Ragona, M. Marelli, L. Polito. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 62:1(2023 Jan 02), pp. e202210140.1-e202210140.6. [10.1002/anie.202210140]

Photo-Induced Microfluidic Production of Ultrasmall Glyco Gold Nanoparticles

C. Lenardi
Methodology
;
R. MATEU FERRANDO
Methodology
;
L. Lay
Investigation
;
M. Marelli
Penultimo
Methodology
;
L. Polito
Ultimo
Supervision
2023

Abstract

Ultra-small gold nanoparticles (UAuNPs) are extremely interesting for applications in nanomedicine thanks to their good stability, biocompatibility, long circulation time and efficient clearance pathways. UAuNPs engineered with glycans (Glyco- UAuNPs) emerged as excellent platforms for many applications since the multiple copies of glycans can mimic the multivalent effect of glycoside clusters. Herein, we unravel a straightforward photo-induced synthesis of Glyco-UAuNPs based on a reliable and robust microfluidic approach. The synthesis occurs at room temperature avoiding the use of any further chemical reductant, templating agents or co-solvents. Exploiting 1H-NMR spectroscopy, we showed that the amount of thiol-ligand exposed on the UAuNPs is linearly correlated to the ligand concentration in the initial mixture. The results pave the way towards the development of a programmable synthetic approach, enabling an accurate design of the engineered UAuNPs or smart hybrid nano- systems.
Settore CHIM/06 - Chimica Organica
H20MCITNIF18LLAY_01 - Glyco-Nanoparticles for Applications in Advance Nanomedicine (NanoCarb) - LAY, LUIGI - H20MCITNIF - Horizon 2020_Marie Skłodowska-Curie actions-Innovative Training Network (ITN)/Individual Fellowships (IF) - 2018
2-nov-2022
https://doi.org/10.1002/anie.202210140
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/945937
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