Compilation of a database, specific for the pesticide active substance and their metabolites, comprising the main genotoxicity endpoints

The terminal residues of pesticide active substances in food and feed commodities need to be duly identified following the requirements of Commission Regulation (EU) No 283/2013 in accordance with Regulation (EC) No 1107/2009. This information is necessary to derive the residue definition for the dietary risk assessment. EFSA initiated in 2009 a work programme to support the preparation of scientific guidance on the establishment of the residue definition for risk assessment. In 2012, the Panel on Plant Protection Products and their Residues (PPR Panel) adopted a scientific opinion on the toxicological relevance of pesticide metabolites for dietary risk assessment. In its opinion, the PPR Panel also indicated that the application of integrated approaches including the combination of QSAR models and read across for the genotoxicity assessment of pesticide residues would imply the availability of a robust database specific for pesticide active substances and their metabolites. The overall objective of the project is the compilation of a database specific for pesticide active substances and their metabolites, which is comprising the different genotoxicity endpoints i.e. point mutations, structural and numerical chromosome aberrations. For each substances and metabolites (and or impurities when available), data collection, data extraction and data entry has been performed according to a methodology agreed by EFSA and the consortium. The database represents a practical tool to complement the in-silico tools i.e. QSAR, grouping and read across for prediction and indication of the genotoxicity hazard. Moreover, the database is expected to increase the specificity and sensitivity of the in-silico tools and to enlarge the chemical domains for their applicability.