Lifespan is determined by complex and tangled mechanisms that are largely unknown. The early postnatal stage has been proposed to play a role in lifespan, but its contribution is still controversial. Here, we show that a short rapamycin treatment during early life can prolong lifespan in Mus musculus and Drosophila melanogaster. Notably, the same treatment at later time points has no effect on lifespan, suggesting that a specific time window is involved in lifespan regulation. We also find that sulfotransferases are upregulated during early rapamycin treatment both in newborn mice and in Drosophila larvae, and transient dST1 overexpression in Drosophila larvae extends lifespan. Our findings unveil a novel link between early-life treatments and long-term effects on lifespan.

Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster / G. Aiello, C. Sabino, D. Pernici, M. Audano, F. Antonica, M. Gianesello, C. Ballabio, A. Quattrone, N. Mitro, A. Romanel, A. Soldano, L. Tiberi. - In: EMBO REPORTS. - ISSN 1469-3178. - 23:9(2022 Sep 05), pp. e55299.1-e55299.19. [10.15252/embr.202255299]

Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster

M. Audano;N. Mitro;
2022

Abstract

Lifespan is determined by complex and tangled mechanisms that are largely unknown. The early postnatal stage has been proposed to play a role in lifespan, but its contribution is still controversial. Here, we show that a short rapamycin treatment during early life can prolong lifespan in Mus musculus and Drosophila melanogaster. Notably, the same treatment at later time points has no effect on lifespan, suggesting that a specific time window is involved in lifespan regulation. We also find that sulfotransferases are upregulated during early rapamycin treatment both in newborn mice and in Drosophila larvae, and transient dST1 overexpression in Drosophila larvae extends lifespan. Our findings unveil a novel link between early-life treatments and long-term effects on lifespan.
aging; early-life treatment; mTOR; sulfotransferases; Aging; Animals; Drosophila; Drosophila melanogaster; Mice; Sirolimus; Drosophila Proteins; Longevity
Settore BIO/10 - Biochimica
DECC18ACORS_01 - Dipartimenti di Eccellenza 2018-2022 - Dipartimento di SCIENZE FARMACOLOGICHE E BIOMOLECOLARI - CORSINI, ALBERTO - DECC - Bando Dipartimenti di Eccellenza - 2018
7-lug-2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/945590
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