Nowadays, most of patients affected by psychiatric disorders are successfully treated with con- servative therapies. Still, a variable percentage of them demonstrate resistance to conventional treatments, and alternative methods can then be considered. During the last 20 years, there is a progressive interest in use of deep brain stimulation (DBS) in mental illnesses. It has become clear nowadays, that this modality may be effectively applied under specific indications in some patients with major depressive disorder, obsessive-compulsive disorder, anorexia ner- vosa and other eating disorders, Tourette syndrome, schizophrenia, substance use disorder, and even pathologically aggressive behavior. Despite the fact that the efficacy of neuromodu- lation with DBS, as well as of various lesional interventions, in cases of mental illnesses is still not fully established, there are several premises for wider applications of such “unclassical” psychiatric treatments in the future. Novel technologies of DBS, developments in non-invasive lesioning using stereotactic radiosurgery and transcranial magnetic resonance–guided focused ultrasound, and advances of neurophysiological and neuroimaging modalities may bolster fur- ther clinical applications of psychiatric neurosurgery, improve its results, and allow for indi- vidually selected treatment strategies tailored to specific needs of the patient.

Role of deep brain stimulation in management of psychiatric disorders / G. Messina, I.G. Vetrano, G. Bonomo, G. Broggi (PROGRESS IN BRAIN RESEARCH). - In: Neurosurgical Management of Psychiatric Disorders, Part A / [a cura di] M.F. Chernov, J.A. Rzaev, R. Martínez-Álvarez. - [s.l] : Elsevier, 2022 Feb 12. - ISBN 9780128237717. - pp. 61-96 [10.1016/bs.pbr.2022.01.026]

Role of deep brain stimulation in management of psychiatric disorders

I.G. Vetrano
Secondo
;
G. Bonomo
Penultimo
;
2022

Abstract

Nowadays, most of patients affected by psychiatric disorders are successfully treated with con- servative therapies. Still, a variable percentage of them demonstrate resistance to conventional treatments, and alternative methods can then be considered. During the last 20 years, there is a progressive interest in use of deep brain stimulation (DBS) in mental illnesses. It has become clear nowadays, that this modality may be effectively applied under specific indications in some patients with major depressive disorder, obsessive-compulsive disorder, anorexia ner- vosa and other eating disorders, Tourette syndrome, schizophrenia, substance use disorder, and even pathologically aggressive behavior. Despite the fact that the efficacy of neuromodu- lation with DBS, as well as of various lesional interventions, in cases of mental illnesses is still not fully established, there are several premises for wider applications of such “unclassical” psychiatric treatments in the future. Novel technologies of DBS, developments in non-invasive lesioning using stereotactic radiosurgery and transcranial magnetic resonance–guided focused ultrasound, and advances of neurophysiological and neuroimaging modalities may bolster fur- ther clinical applications of psychiatric neurosurgery, improve its results, and allow for indi- vidually selected treatment strategies tailored to specific needs of the patient.
Psychiatric neurosurgery; Deep brain stimulation; Stereotactic targeting; Depression; Obsessive-compulsive disorder; Eating disorders; Anorexia nervosa; Tourette syndrome; Schizophrenia; Addictions
Settore MED/27 - Neurochirurgia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/945409
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